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Table 2 The levels of 14 markers in nasopharyngeal carcinoma (NPC) patients and control subjects

From: Decreased macrophage inflammatory protein (MIP)-1α and MIP-1β increase the risk of developing nasopharyngeal carcinoma

Marker Case–control study Nested case–control study
NPC patients (pg/mL) Controls (pg/mL) P NPC patients (pg/mL) Controls (pg/mL) P
Median P25 P75 Median P25 P75 Median P25 P75 Median P25 P75
EGF 209.3 125.8 327.1 392.5 238.9 594.4 < 0.001 442.3 274.5 583.5 477.0 333.4 629.0 0.26
Eotaxin 126.6 95.4 174.4 143.6 106.2 186.9 0.098 140.0 96.1 195.4 139.1 96.0 212.0 0.86
GCSF 6.5 1.6 15.6 15.6 4.3 50.9 < 0.001 22.8 7.6 40.6 18.6 5.8 31.2 0.13
Fractalkine 11.4 11.4 11.4 59.2 11.4 211.2 < 0.001 92.9 11.4 547.2 92.9 11.4 380.4 0.76
IFN-γ 6.0 1.6 25.5 10.0 3.6 24.5 0.079 5.8 1.6 11.6 4.9 1.6 11.7 0.87
GRO 940.6 731.4 1272.0 1406.0 964.6 2309.5 < 0.001 1926.0 1346.5 4808.5 1615.5 1209.5 2652.5 0.13
MDC 861.3 669.8 1122.0 894.4 590.7 1179.0 0.89 883.3 625.1 1248.5 814.0 628.0 1122.0 0.55
IL-1α 4.7 4.7 4.7 4.7 4.7 68.8 < 0.001 4.7 4.7 24.4 4.7 4.7 98.0 0.08
IL-7 1.6 1.6 7.3 3.2 1.6 11.9 0.11 3.3 1.6 5.3 1.6 1.6 3.7 0.035
IL-8 20.4 7.8 39.8 16.4 7.5 34.0 0.48 58.8 7.3 269.6 108.2 13.3 380.4 0.106
MCP-1 465.2 348.3 598.1 400.0 232.9 568.8 0.004 617.3 400.0 789.0 598.1 450.8 788.8 0.38
MIP-1α 1.6 1.6 66.5 29.0 1.6 95.4 0.023 25.9 1.6 57.0 32.6 4.3 114.5 0.105
MIP-1β 51.5 25.8 82.6 62.6 32.0 102.2 0.036 69.8 31.2 116.7 88.5 43.8 157.8 0.045
VEGF 297.7 129.0 594.4 279.6 129.0 459.3 0.46 218.8 79.0 357.2 188.2 88.5 364.1 0.73
  1. NPC nasopharyngeal carcinoma, P computed using a Wilcoxon rank-sum test, EGF epidermal growth factor, GCSF granulocyte colony-stimulating factor, IFN-γ interferon gamma, GRO growth-regulated oncogene, MDC macrophage-derived chemokine, IL-1α interleukin-1 alpha, IL-7 interleukin-7, IL-8 interleukin-8, MCP-1 monocyte chemotactic protein-1, MIP-1α macrophage inflammatory protein-1 alpha, MIP-1β macrophage inflammatory protein-1 beta, VEGF vascular endothelial growth factor