Table 1 Clinicopathological characteristics of patients with esophageal squamous cell carcinoma
Variable | The GEO datasetsa | The experimental set | ||||
|---|---|---|---|---|---|---|
Number of patients | 5-year OS rate (%) | P valueb | Number of patients | 5-year OS rate (%) | P valueb | |
Total | 119 | Â | Â | 105 | Â | Â |
Age (years) | ||||||
 ≤ 59 | 89 | 48.31 | 0.03 | 63 | 58.73 | 0.69 |
 > 59 | 90 | 33.33 | 42 | 54.76 | ||
Sex | ||||||
 Female | 33 | 33.33 | 0.30 | 25 | 48.00 | 0.16 |
 Male | 146 | 42.47 | 80 | 60.00 | ||
Tumor location | ||||||
 Upper thorax | 20 | 25.00 | 0.10 | 7 | 71.4 | 0.15 |
 Middle thorax | 97 | 40.21 | 54 | 61.11 | ||
 Lower thorax | 62 | 46.78 | 44 | 50.00 | ||
Histological grade | ||||||
 G1 | 49 | 28.57 | 0.02 | 15 | 60.00 | 0.16 |
 G2 | 98 | 44.90 | 73 | 64.29 | ||
 G3 | 32 | 46.88 | 17 | 47.06 | ||
Primary tumor | ||||||
 T1 | 12 | 41.67 | 0.04 | 21 | 71.42 | 0.03 |
 T2 | 27 | 40.74 | 63 | 63.49 | ||
 T3 | 110 | 44.55 | 21 | 31.58 | ||
 T4 | 30 | 26.67 |  |  |  | |
Regional lymph nodes | ||||||
 N0 | 83 | 56.62 | < 0.01 | 50 | 68.00 | < 0.01 |
 N1 | 62 | 27.41 | 32 | 56.25 | ||
 N2 | 22 | 27.27 | 16 | 37.50 | ||
 N3 | 12 | 25.00 | 7 | 28.50 | ||
pTNM stage | ||||||
 I | 10 | 70.00 | 0.00 | 6 | 33.30 | 0.00 |
 II | 77 | 53.25 | 48 | 70.80 | ||
 III | 92 | 27.17 | 51 | 47.05 | ||
Adjuvant therapy | ||||||
 Unknown | 45 | 64.44 |  | 0 |  |  |
 No | 30 | 30.00 | 0.50 | 43 | 58.14 | 0.70 |
 Yes | 104 | 33.65 | 62 | 56.45 | ||
 Radiotherapy | Unknown |  |  | 18 | 48.83 | 0.11 |
 Chemotherapy | Unknown |  |  | 19 | 59.09 | |
 Radiotherapy + chemotherapy | Unknown |  |  | 25 | 48.00 | |