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Table 1 Clinicopathological characteristics of patients with esophageal squamous cell carcinoma
| Variable | The GEO datasetsa | The experimental set | ||||
|---|---|---|---|---|---|---|
| Number of patients | 5-year OS rate (%) | P valueb | Number of patients | 5-year OS rate (%) | P valueb | |
| Total | 119 | 105 | ||||
| Age (years) | ||||||
| ≤ 59 | 89 | 48.31 | 0.03 | 63 | 58.73 | 0.69 |
| > 59 | 90 | 33.33 | 42 | 54.76 | ||
| Sex | ||||||
| Female | 33 | 33.33 | 0.30 | 25 | 48.00 | 0.16 |
| Male | 146 | 42.47 | 80 | 60.00 | ||
| Tumor location | ||||||
| Upper thorax | 20 | 25.00 | 0.10 | 7 | 71.4 | 0.15 |
| Middle thorax | 97 | 40.21 | 54 | 61.11 | ||
| Lower thorax | 62 | 46.78 | 44 | 50.00 | ||
| Histological grade | ||||||
| G1 | 49 | 28.57 | 0.02 | 15 | 60.00 | 0.16 |
| G2 | 98 | 44.90 | 73 | 64.29 | ||
| G3 | 32 | 46.88 | 17 | 47.06 | ||
| Primary tumor | ||||||
| T1 | 12 | 41.67 | 0.04 | 21 | 71.42 | 0.03 |
| T2 | 27 | 40.74 | 63 | 63.49 | ||
| T3 | 110 | 44.55 | 21 | 31.58 | ||
| T4 | 30 | 26.67 | ||||
| Regional lymph nodes | ||||||
| N0 | 83 | 56.62 | < 0.01 | 50 | 68.00 | < 0.01 |
| N1 | 62 | 27.41 | 32 | 56.25 | ||
| N2 | 22 | 27.27 | 16 | 37.50 | ||
| N3 | 12 | 25.00 | 7 | 28.50 | ||
| pTNM stage | ||||||
| I | 10 | 70.00 | 0.00 | 6 | 33.30 | 0.00 |
| II | 77 | 53.25 | 48 | 70.80 | ||
| III | 92 | 27.17 | 51 | 47.05 | ||
| Adjuvant therapy | ||||||
| Unknown | 45 | 64.44 | 0 | |||
| No | 30 | 30.00 | 0.50 | 43 | 58.14 | 0.70 |
| Yes | 104 | 33.65 | 62 | 56.45 | ||
| Radiotherapy | Unknown | 18 | 48.83 | 0.11 | ||
| Chemotherapy | Unknown | 19 | 59.09 | |||
| Radiotherapy + chemotherapy | Unknown | 25 | 48.00 | |||
