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Fig. 1 | Cancer Communications

Fig. 1

From: EYA4 inhibits hepatocellular carcinoma growth and invasion by suppressing NF-κB-dependent RAP1 transactivation

Fig. 1

The overexpression of eyes absent homolog 4 (EYA4) antagonized the proliferation, clonogenicity, invasiveness and xenograft tumor growth of human hepatocellular carcinoma (HCC) cells. a Quantitative real-time polymerase chain reaction (qRT-PCR) and Western blotting analyses showed elevated EYA4 expression levels in EYA4-expressing plasmid (pEYA) transfectants. b–d Suppressive effects of EYA4 overexpression on cell proliferation (b), colony formation (c) and transwell invasion (d). e, f Tumor growth curves (left panel) and images (right panel) of xenografts of Huh-7 (e) and PLC5 (f) cells after an intratumoral injection of pEYA4. **P < 0.01 between groups. EYA4 eyes absent homolog 4, GAPDH glyceraldehyde 3-phosphate dehydrogenase, HCC hepatocellular carcinoma, pEYA4 EYA4-expressing plasmid, qRT-PCR quantitative real-time polymerase chain reaction

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Cancer Communications

ISSN: 2523-3548

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