Table 2 Univariate and multivariate cox regression analysis for overall survival in patients with ESCC
Characteristic | Univariate analysis | Multivariate analysis | ||||
|---|---|---|---|---|---|---|
HR | 95% CI | P value | HR | 95% CI | P value | |
Age (years) | ||||||
≤ 45 vs. 46–59 vs. ≥ 60 | 1.002 | 0.990–1.015 | 0.720 | – | – | – |
Sex | ||||||
Female vs. male | 0.769 | 0.607–0.975 | 0.030 | 0.865 | 0.680–1.101 | 0.239 |
Smoking status | ||||||
Yes vs. no | 1.176 | 0.944–1.465 | 0.149 | – | – | – |
Drinking status | ||||||
Yes vs. no | 1.195 | 0.922–1.548 | 0.178 | – | – | – |
Weight loss rate | ||||||
0 vs. > 0% to ≤ 5.0% vs. > 5.0% to ≤ 10.0% vs. > 10.0% | 1.168 | 1.047–1.302 | 0.005 | 1.118 | 1.000–1.251 | 0.060 |
BMI (kg/m2) | ||||||
< 18.5 vs. ≥ 18.5 to < 25.0 vs. ≥ 25.0 | 0.970 | 0.779–1.207 | 0.784 | – | – | – |
Tumor location | ||||||
Upper vs. middle vs. lower | 0.932 | 0.767–1.134 | 0.483 | – | – | – |
Tumor grade | ||||||
G1 vs. G2 vs. G3 | 1.489 | 1.271–1.745 | < 0.001 | 1.373 | 1.164–1.621 | < 0.001 |
pT category | ||||||
T1 vs. T2 vs. T3 vs. T4 | 1.642 | 1.308–2.062 | < 0.001 | 1.257 | 0.982–1.611 | 0.070 |
pN category | ||||||
N0 vs. N1 vs. N2 vs. N3 | 1.820 | 1.594–2.079 | < 0.001 | 1.474 | 1.181–1.839 | 0.001 |
pTNM stage | ||||||
Stage I vs. stage II vs. stage III | 2.270 | 1.832–2.813 | < 0.001 | 1.237 | 0.872–1.754 | 0.233 |
Complications | ||||||
None vs. anastomotic leakage vs. pneumonia vs. others | 1.118 | 0.961–1.299 | 0.148 | – | – | – |
T2DM | ||||||
With T2DM vs. without T2DM | 0.896 | 0.719–1.116 | 0.326 | – | – | – |