Selection of candidates for surgery as local therapy among early-stage small cell lung cancer patients: a population-based analysis

Table 4 Studies that support surgery as part of the multimodality management for selected patients with SCLC

First author and year of publication	Recruitment period	Indications of surgery as local therapy
First author and year of publication	Recruitment period	VALG or TNM stage	Tumor size	N category
Rostad, 2004 [12]	1993–1999	I^a (T1-2N0, 6th or earlier edition)	Any size	N0
Lim, 2008 [15]	1980–2006	I–II (6th or earlier edition)	Any size	N0
Hanagiri, 2009 [16]	1980–2004	I and part^b of II-IIIa	Any size	N0-2
Yu, 2010 [14]	1988–2004	I (T1-2N0, 6th or earlier edition)^c	Any size	N0
Schreiber, 2010 [9]	1998–2002	Limited stage (T1-4, Nx-0)	Any size	N0
Weksler, 2012 [18]	1988–2007	I-II (6th or earlier edition)	Any size	N0-1
Luchtenborg, 2014 [11]	1998–2009	Early stage based on similar principles for NSCLC	Any size	N0-1
Combs, 2015 [17]	1998–2011	I-III (6th or 7th edition)	Any size	N0-2
NCCN Guideline [19]		T1-2N0 (7th edition)	0–7 cm	N0
The present study	2004–2013	T1-2N0 (8th edition)	0–5 cm	N0

SCLC small cell lung cancer, VALG Veterans Administration Lung Study Group, NSCLC non-small cell lung cancer, NCCN National Comprehensive Cancer Network
^aPatients with stage I lesion located at the peripheral site
^bPatients with stage II–IIIa SCLC who responded to induction chemotherapy
^cPatients with stage I SCLC who underwent lobectomy and had reasonable overall survival outcomes