Fig. 5
From: Follistatin-like protein 1 plays a tumor suppressor role in clear-cell renal cell carcinoma
Effect of FSTL1 knockdown on epithelial-to-mesenchymal transition (EMT) and NF-κB signaling. a Levels of IL-6 mRNA in NRCC-shFSTL1, 786-O-shFSTL1, ACHN-shFSTL1, and in ACHN-topo-FSTL1. b Levels of E-cadherin mRNA in ccRCC cell lines with FSTL1 knockdown and in ACHN cells with topo-FSTL1. c Levels of N-cadherin mRNA in ccRCC cell lines with FSTL1 knockdown and in ACHN cells with topo-FSTL1. d FSTL1 knockdown speeded up the degradation of NF-κB inhibitor (IκBα) in ccRCC cells at 60 min following TNFα treatment. The relative expression of IκBα at 60 min is higher in NRCC-shScramble cells (57.33 ± 4.37, n = 3) than in NRCC-shFSTL1-1 cells (36.67 ± 5.84, n = 3, P = 0.036) and NRCC-shFSTL1-2 cells (33.67 ± 5.04, n = 3, P = 0.032)