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Table 1 Associations between serum EBV DNA copy number and GTVnd as well as clinical demographic characteristics of patients with N1 nasopharyngeal carcinoma

From: Prognostic values of the integrated model incorporating the volume of metastatic regional cervical lymph node and pretreatment serum Epstein–Barr virus DNA copy number in predicting distant metastasis in patients with N1 nasopharyngeal carcinoma

Characteristic EBV DNA copy numbera P value
≤ 4000 copies/mL (n = 477) > 4000 copies/mL (n = 310)
GTVnd (mL)    < 0.001
 ≤ 18.9 415 (87.0) 223 (71.9)  
 > 18.9 62 (13.0) 87 (28.1)  
Gender    0.142
 Male 336 (70.4) 234 (75.5)  
 Female 141 (29.6) 76 (24.5)  
Age (years)    0.558
 > 45 215 (45.1) 147 (47.4)  
 ≤ 45 262 (54.9) 163 (52.6)  
T category    < 0.001
 T1–2 164 (34.4) 57 (18.4)  
 T3–4 313 (65.6) 253 (81.6)  
Treatment method    < 0.001
 Radiotherapy alone 55 (11.5) 14 (4.5)  
 CCRT 280 (58.7) 130 (41.9)  
 NACT + CCRT 142 (29.8) 166 (53.5)  
  1. EBV pretreatment Epstein–Barr virus, GTVnd gross tumor volume of lymph nodes, CCRT concurrent chemoradiotherapy, NACT neoadjuvant chemotherapy
  2. aAll values are presented as number of patients followed by percentage in parentheses