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Table 2 Univariate analyses of prognostic factors for disease-free survival and overall survival of patients with stage III colon cancer

From: Prognostic value of preoperative prognostic nutritional index and its associations with systemic inflammatory response markers in patients with stage III colon cancer

Variable Disease-free survival Overall survival
HR (95% CI) P value HR (95% CI) P value
Age (> 60 years vs. ≤ 60 years) 1.401 (0.804–2.443) 0.234 1.390 (0.661–2.925) 0.385
Sex (male vs. female) 1.943 (1.081–3.494) 0.026 1.902 (0.871–4.154) 0.107
BMI(< 18.5 kg/m2 vs. ≥ 18.5 kg/m2) 0.760 (0.274–2.107) 0.598 1.892 (0.724–4.944) 0.193
Hemoglobin (< 90 g/L vs. ≥ 90 g/L) 0.965 (0.455–2.047) 0.926 0.818 (0.285–2.346) 0.709
Tumor location (right-sided colon vs. left-sided colon) 1.356 (0.787–2.334) 0.272 2.243 (1.089–4.619) 0.028
Tumor size (> 4 cm vs. ≤ 4 cm) 0.941 (0.548–1.613) 0.824 1.046 (0.511–2.140) 0.902
Differentiation (poor vs. well/moderate) 1.143 (0.621–2.106) 0.667 1.181 (0.525–2.656) 0.687
T stage (T4 vs. T1–3) 1.553 (0.890–2.708) 0.121 1.709 (0.797–3.668) 0.169
N stage (N2 vs. N1) 1.573 (0.907–2.729) 0.107 1.487 (0.716–3.089) 0.287
CEA (> 5 ng/mL vs. ≤ 5 ng/mL) 1.557 (0.908–2.671) 0.107 0.987 (0.479–2.034) 0.972
Adjuvant chemotherapy (6–8 cycles vs. < 6 cycles) 0.590 (0.320–1.087) 0.091 0.308 (0.148–0.640) 0.002
LMR (> 4.00 vs. ≤ 4.00) 0.840 (0.488–1.447) 0.530 0.759 (0.365–1.578) 0.460
NLR (> 2.05 vs. ≤ 2.05) 0.915 (0.534–1.568) 0.746 0.872 (0.425–1.789) 0.708
PLR (> 142.99 vs. ≤ 142.99) 1.067 (0.622–1.831) 0.812 1.091 (0.533–2.237) 0.811
PNI (≤ 49.22 vs. > 49.22) 1.889 (1.094–3.262) 0.023 2.353 (1.118–4.950) 0.024
  1. HR hazard ratio, CI confidence interval, BMI body mass index, CEA carcinoembryonic antigen, LMR lymphocyte-to-monocyte ratio, NLR neutrophil-to-lymphocyte ratio, PLR platelet-to-lymphocyte ratio, PNI prognostic nutritional index