|
Sites of first recurrence
|
Emergence level of plasma EBV DNA during posttreatment follow-up
|
AUC (95% CI)
|
Sensitivity (%)
|
Specificity (%)
|
Accuracy (%)
|
PPV (%)
|
NPV (%)
|
|---|
|
Any recurrence
|
| |
EBV DNA > 0 copy/mL
|
0.804 (0.741–0.868)
|
73.6
|
87.2
|
84.7
|
57.0
|
93.5
|
| |
EBV DNA > 500 copies/mL
|
0.781 (0.712–0.851)
|
63.9
|
92.3
|
87.0
|
65.7
|
91.7
|
| |
EBV DNA > 1000 copies/mL
|
0.759 (0.686–0.832)
|
56.9
|
94.9
|
87.8
|
71.9
|
90.5
|
|
Distant metastasis
|
| |
EBV DNA > 0 copy/mL
|
0.882 (0.828–0.935)
|
93.9
|
82.4
|
83.4
|
33.3
|
99.3
|
| |
EBV DNA > 500 copies/mL
|
0.831 (0.748–0.915)
|
78.8
|
87.5
|
86.8
|
37.1
|
97.8
|
| |
EBV DNA > 1000 copies/mL
|
0.817 (0.725–0.908)
|
72.7
|
90.6
|
89.1
|
42.1
|
97.3
|
|
Locoregional recurrence alone
|
| |
EBV DNA > 0 copy/mL
|
0.679 (0.584–0.775)
|
56.4
|
79.5
|
77.1
|
23.7
|
94.2
|
| |
EBV DNA > 500 copies/mL
|
0.684 (0.585–0.783)
|
51.3
|
85.5
|
82.0
|
28.6
|
93.9
|
| |
EBV DNA > 1000 copies/mL
|
0.660 (0.559–0.762)
|
43.6
|
88.4
|
83.9
|
29.8
|
93.3
|
-
ROC receiver operating characteristic, AUC area under the ROC curve, PPV positive predictive value, NPV negative predictive value, CI confidence interval
