Table 4 Diagnostic value of plasma EBV DNA for predicting tumor recurrence in the 385 patients with NPC who were treated with IMRT
Sites of first recurrence | Emergence level of plasma EBV DNA during posttreatment follow-up | AUC (95% CI) | Sensitivity (%) | Specificity (%) | Accuracy (%) | PPV (%) | NPV (%) |
|---|---|---|---|---|---|---|---|
Any recurrence | |||||||
EBV DNA > 0 copy/mL | 0.804 (0.741–0.868) | 73.6 | 87.2 | 84.7 | 57.0 | 93.5 | |
EBV DNA > 500 copies/mL | 0.781 (0.712–0.851) | 63.9 | 92.3 | 87.0 | 65.7 | 91.7 | |
EBV DNA > 1000 copies/mL | 0.759 (0.686–0.832) | 56.9 | 94.9 | 87.8 | 71.9 | 90.5 | |
Distant metastasis | |||||||
EBV DNA > 0 copy/mL | 0.882 (0.828–0.935) | 93.9 | 82.4 | 83.4 | 33.3 | 99.3 | |
EBV DNA > 500 copies/mL | 0.831 (0.748–0.915) | 78.8 | 87.5 | 86.8 | 37.1 | 97.8 | |
EBV DNA > 1000 copies/mL | 0.817 (0.725–0.908) | 72.7 | 90.6 | 89.1 | 42.1 | 97.3 | |
Locoregional recurrence alone | |||||||
EBV DNA > 0 copy/mL | 0.679 (0.584–0.775) | 56.4 | 79.5 | 77.1 | 23.7 | 94.2 | |
EBV DNA > 500 copies/mL | 0.684 (0.585–0.783) | 51.3 | 85.5 | 82.0 | 28.6 | 93.9 | |
EBV DNA > 1000 copies/mL | 0.660 (0.559–0.762) | 43.6 | 88.4 | 83.9 | 29.8 | 93.3 | |