Skip to main content

Advertisement

Table 4 Diagnostic value of plasma EBV DNA for predicting tumor recurrence in the 385 patients with NPC who were treated with IMRT

From: Prognostic value of plasma Epstein–Barr virus DNA level during posttreatment follow-up in the patients with nasopharyngeal carcinoma having undergone intensity-modulated radiotherapy

Sites of first recurrence Emergence level of plasma EBV DNA during posttreatment follow-up AUC (95% CI) Sensitivity (%) Specificity (%) Accuracy (%) PPV (%) NPV (%)
Any recurrence
  EBV DNA > 0 copy/mL 0.804 (0.741–0.868) 73.6 87.2 84.7 57.0 93.5
  EBV DNA > 500 copies/mL 0.781 (0.712–0.851) 63.9 92.3 87.0 65.7 91.7
  EBV DNA > 1000 copies/mL 0.759 (0.686–0.832) 56.9 94.9 87.8 71.9 90.5
Distant metastasis
  EBV DNA > 0 copy/mL 0.882 (0.828–0.935) 93.9 82.4 83.4 33.3 99.3
  EBV DNA > 500 copies/mL 0.831 (0.748–0.915) 78.8 87.5 86.8 37.1 97.8
  EBV DNA > 1000 copies/mL 0.817 (0.725–0.908) 72.7 90.6 89.1 42.1 97.3
Locoregional recurrence alone
  EBV DNA > 0 copy/mL 0.679 (0.584–0.775) 56.4 79.5 77.1 23.7 94.2
  EBV DNA > 500 copies/mL 0.684 (0.585–0.783) 51.3 85.5 82.0 28.6 93.9
  EBV DNA > 1000 copies/mL 0.660 (0.559–0.762) 43.6 88.4 83.9 29.8 93.3
  1. ROC receiver operating characteristic, AUC area under the ROC curve, PPV positive predictive value, NPV negative predictive value, CI confidence interval