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Table 3 Biological pathways with increased glutamine or glutamate influx across 11 types of cancer

From: Systematic analyses of glutamine and glutamate metabolisms across different cancer types

Pathway Substrate → product Cancer type(s)
Purine/pyrimidine metabolisms Glutamine → nucleotides BRCA, KIRC
Biomass production Glutamine → biomass PRAD, THCA
UDP-GlcNAc metabolism Glutamine → UDP-GlcNAc BRCA, PRAD
Asparagine metabolism Glutamine → asparagine BLCA, LUAD
Proline metabolism Glutamine → proline PRAD
Serine metabolism Glutamate → serine BLCA
GSH metabolism Glutamate → GSH BRCA, KICH, LUAD
  1. UDP-GlcNAc, uridine diphosphate N-acetylglucosamine; GSH, glutathione