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Table 3 Univariate and multivariate Cox regression analyses of prognostic factors for 5-year disease-free survival in patients with high and low ER-β expression

From: Expression of voltage-gated sodium channel Nav1.5 in non-metastatic colon cancer and its associations with estrogen receptor (ER)-β expression and clinical outcomes

Variables Low ER-β expression (n = 51) High ER-β expression (n = 206)
Univariate HR (95% CI) P value Univariate HR (95% CI) P value Multivariate HR (95% CI) P value
Gender (female vs. male) 1.054 (0.339–3.271) 0.928 0.999 (0.558–1.699) 0.998   
Age (> 60 years vs. ≤ 60 years) 1.313 (0.416–4.139) 0.642 1.604 (0.931–2.766) 0.089   
Tumor location (right colon vs. left colon) 1.282 (0.413–3.975) 0.667 0.767 (0.429–1.373) 0.373   
Tumor size (> 5 cm vs. ≤ 5 cm) 2.227 (0.616–8.419) 0.217 0.817 (0.476–1.402) 0.463   
Tumor differentiation (poor vs. well to moderate) 1.598 (0.206–12.423) 0.654 1.462 (0.626–3.415) 0.380   
T category (T3-4 vs. T1-2) 26.1 (0.030–22,868.187) 0.345 1.551 (0.733–3.283) 0.251   
N category (N1-2 vs. N0) 5.179 (1.633–16.418) 0.005 2.086 (1.224–3.556) 0.007 2.232 (1.309–3.808) 0.003
Nav1.5 expression (high vs. low) 1.830 (0.401–8.362) 0.435 4.155 (1.012–17.056) 0.048 4.653 (1.131–19.142) 0.033
  1. HR hazard ratio, CI confidence interval, ER-β estrogen receptor-β