Expression of voltage-gated sodium channel Nav1.5 in non-metastatic colon cancer and its associations with estrogen receptor (ER)-β expression and clinical outcomes

Table 3 Univariate and multivariate Cox regression analyses of prognostic factors for 5-year disease-free survival in patients with high and low ER-β expression

Variables	Low ER-β expression (n = 51)		High ER-β expression (n = 206)
Variables	Univariate HR (95% CI)	P value	Univariate HR (95% CI)	P value	Multivariate HR (95% CI)	P value
Gender (female vs. male)	1.054 (0.339–3.271)	0.928	0.999 (0.558–1.699)	0.998
Age (> 60 years vs. ≤ 60 years)	1.313 (0.416–4.139)	0.642	1.604 (0.931–2.766)	0.089
Tumor location (right colon vs. left colon)	1.282 (0.413–3.975)	0.667	0.767 (0.429–1.373)	0.373
Tumor size (> 5 cm vs. ≤ 5 cm)	2.227 (0.616–8.419)	0.217	0.817 (0.476–1.402)	0.463
Tumor differentiation (poor vs. well to moderate)	1.598 (0.206–12.423)	0.654	1.462 (0.626–3.415)	0.380
T category (T3-4 vs. T1-2)	26.1 (0.030–22,868.187)	0.345	1.551 (0.733–3.283)	0.251
N category (N1-2 vs. N0)	5.179 (1.633–16.418)	0.005	2.086 (1.224–3.556)	0.007	2.232 (1.309–3.808)	0.003
Nav1.5 expression (high vs. low)	1.830 (0.401–8.362)	0.435	4.155 (1.012–17.056)	0.048	4.653 (1.131–19.142)	0.033