Table 3 Univariate and multivariate Cox regression analyses of prognostic factors for 5-year disease-free survival in patients with high and low ER-β expression
Variables | Low ER-β expression (n = 51) | High ER-β expression (n = 206) | ||||
|---|---|---|---|---|---|---|
Univariate HR (95% CI) | P value | Univariate HR (95% CI) | P value | Multivariate HR (95% CI) | P value | |
Gender (female vs. male) | 1.054 (0.339–3.271) | 0.928 | 0.999 (0.558–1.699) | 0.998 | ||
Age (> 60 years vs. ≤ 60 years) | 1.313 (0.416–4.139) | 0.642 | 1.604 (0.931–2.766) | 0.089 | ||
Tumor location (right colon vs. left colon) | 1.282 (0.413–3.975) | 0.667 | 0.767 (0.429–1.373) | 0.373 | ||
Tumor size (> 5 cm vs. ≤ 5 cm) | 2.227 (0.616–8.419) | 0.217 | 0.817 (0.476–1.402) | 0.463 | ||
Tumor differentiation (poor vs. well to moderate) | 1.598 (0.206–12.423) | 0.654 | 1.462 (0.626–3.415) | 0.380 | ||
T category (T3-4 vs. T1-2) | 26.1 (0.030–22,868.187) | 0.345 | 1.551 (0.733–3.283) | 0.251 | ||
N category (N1-2 vs. N0) | 5.179 (1.633–16.418) | 0.005 | 2.086 (1.224–3.556) | 0.007 | 2.232 (1.309–3.808) | 0.003 |
Nav1.5 expression (high vs. low) | 1.830 (0.401–8.362) | 0.435 | 4.155 (1.012–17.056) | 0.048 | 4.653 (1.131–19.142) | 0.033 |