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Table 2 Univariate and multivariate Cox regression analyses of prognostic predictors for 5-year disease-free survival in 269 patients with non-metastatic colon cancer undergoing radical resection

From: Expression of voltage-gated sodium channel Nav1.5 in non-metastatic colon cancer and its associations with estrogen receptor (ER)-β expression and clinical outcomes

Variables Univariate analysis Multivariate analysis
HR (95% CI) P value HR (95% CI) P value
Nav1.5 expression (high vs. low) 2.504 (1.007–6.227) 0.048 2.738 (1.100–6.819) 0.030
Gender (female vs. male) 0.984 (0.611–1.586) 1.586   
Age (> 60 years vs. ≤ 60 years) 1.577 (0.972–2.557) 0.065   
Tumor location (right-sided colon vs. left-sided colon) 0.828 (0.498–1.377) 0.467   
Tumor size (> 5 cm vs. ≤ 5 cm) 0.987 (0.613–1.589) 0.957   
Tumor differentiation (poor vs. well to moderate) 1.550 (0.709–3.391) 0.272   
T category (T3-4 vs. T1-2) 1.942 (0.928–4.061) 0.078   
N category (N1-2 vs. N0) 2.524 (1.566–4.070) < 0.001 2.633 (1.632–4.248) < 0.001
Preoperative CEA (> 5 ng/mL vs. ≤ 5 ng/mL)a 1.726 (1.049–2.841) 0.032   
Preoperative CA199 (> 35 U/mL vs. ≤ 35 U/mL)b 1.486 (0.800–2.760) 0.210   
Adjuvant chemotherapy (yes vs. no) 1.607 (0.735–3.513) 0.235   
ER-β expression (high vs. low)c 1.163 (0.623–2.171) 0.636   
  1. HR hazard ratio, CI confidence interval, ER-β estrogen receptor-β, CEA carcinoembryonic antigen
  2. aThe data of preoperative CEA level were available in 246 patients
  3. bThe data of preoperative CA199 level were available in 222 patients
  4. cThe IHC scores of ER-β expression were obtained in 257 patients