Expression of voltage-gated sodium channel Nav1.5 in non-metastatic colon cancer and its associations with estrogen receptor (ER)-β expression and clinical outcomes

Table 2 Univariate and multivariate Cox regression analyses of prognostic predictors for 5-year disease-free survival in 269 patients with non-metastatic colon cancer undergoing radical resection

Variables	Univariate analysis		Multivariate analysis
Variables	HR (95% CI)	P value	HR (95% CI)	P value
Nav1.5 expression (high vs. low)	2.504 (1.007–6.227)	0.048	2.738 (1.100–6.819)	0.030
Gender (female vs. male)	0.984 (0.611–1.586)	1.586
Age (> 60 years vs. ≤ 60 years)	1.577 (0.972–2.557)	0.065
Tumor location (right-sided colon vs. left-sided colon)	0.828 (0.498–1.377)	0.467
Tumor size (> 5 cm vs. ≤ 5 cm)	0.987 (0.613–1.589)	0.957
Tumor differentiation (poor vs. well to moderate)	1.550 (0.709–3.391)	0.272
T category (T3-4 vs. T1-2)	1.942 (0.928–4.061)	0.078
N category (N1-2 vs. N0)	2.524 (1.566–4.070)	< 0.001	2.633 (1.632–4.248)	< 0.001
Preoperative CEA (> 5 ng/mL vs. ≤ 5 ng/mL)^a	1.726 (1.049–2.841)	0.032
Preoperative CA199 (> 35 U/mL vs. ≤ 35 U/mL)^b	1.486 (0.800–2.760)	0.210
Adjuvant chemotherapy (yes vs. no)	1.607 (0.735–3.513)	0.235
ER-β expression (high vs. low)^c	1.163 (0.623–2.171)	0.636

HR hazard ratio, CI confidence interval, ER-β estrogen receptor-β, CEA carcinoembryonic antigen
^aThe data of preoperative CEA level were available in 246 patients
^bThe data of preoperative CA199 level were available in 222 patients
^cThe IHC scores of ER-β expression were obtained in 257 patients

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