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Table 1 Associations of clinicopathologic characteristics with Nav1.5 expression in 269 patients with colon cancer
| Characteristics | Total patients | Nav1.5 low expression | Nav1.5 high expression | P value |
|---|---|---|---|---|
| Clinical parameter | ||||
| Gender | 0.384 | |||
| Male | 145 (53.9) | 18 (12.4) | 127 (87.6) | |
| Female | 124 (46.1) | 20 (16.1) | 104 (83.9) | |
| Age (years) | ||||
| ≤ 60 | 136 (50.6) | 21 (15.4) | 115 (84.6) | 0.532 |
| > 60 | 133 (49.4) | 17 (12.8) | 116 (87.2) | |
| Tumor localization | 0.503 | |||
| Right-sided colon | 98 (36.4) | 12 (12.2) | 86 (87.8) | |
| Left-sided colon | 171 (63.6) | 26 (15.2) | 145 (84.8) | |
| Preoperative serum CEA (ng/mL)a | 0.011 | |||
| ≤ 5 | 154 (62.6) | 29 (18.8) | 125 (81.2) | |
| > 5 | 92 (37.4) | 6 (6.5) | 86 (93.5) | |
| Preoperative serum CA199 (U/mL)b | 0.947 | |||
| ≤ 35 | 180 (81.1) | 25 (13.9) | 155 (86.1) | |
| > 35 | 42 (18.9) | 6 (14.3) | 36 (85.7) | |
| Adjuvant chemotherapy | 0.556 | |||
| Yes | 228 (84.8) | 31 (81.6) | 197 (85.3) | |
| No | 41 (15.2) | 7 (18.4) | 34 (14.7) | |
| Pathologic feature | ||||
| Tumor size (cm) | 0.863 | |||
| ≤ 5 | 138 (51.3) | 19 (13.8) | 119 (86.2) | |
| > 5 | 131 (48.7) | 19 (14.5) | 112 (85.5) | |
| Tumor differentiation | 0.983 | |||
| Well and moderate | 248 (92.2) | 35 (14.1) | 213 (85.9) | |
| Poor | 21 (7.8) | 3 (14.3) | 18 (85.7) | |
| T category | 0.385 | |||
| T1 | 17 (6.3) | 8 (47.1) | 9 (52.9) | |
| T2 | 50 (18.6) | 4 (8.0) | 46 (92.0) | |
| T3 | 108 (40.1) | 9 (8.3) | 99 (91.7) | |
| T4 | 94 (34.9) | 17 (18.1) | 77 (81.9) | |
| N category | 0.545 | |||
| N0 | 195 (72.5) | 26 (13.3) | 169 (86.7) | |
| N1-2 | 74 (27.5) | 12 (16.2) | 62 (83.8) | |
| TNM stage | 0.836 | |||
| I | 61 (22.7) | 11 (18.0) | 50 (82.0) | |
| II | 134 (49.8) | 15 (11.2) | 119 (88.8) | |
| III | 74 (27.5) | 12 (16.2) | 62 (83.8) | |
| ER-β statusc | 0.024 | |||
| Low expression | 51 (19.8) | 12 (23.5) | 39 (76.5) | |
| High expression | 206 (80.2) | 23 (11.2) | 183 (88.8) | |
