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Table 1 Associations of clinicopathologic characteristics with Nav1.5 expression in 269 patients with colon cancer

From: Expression of voltage-gated sodium channel Nav1.5 in non-metastatic colon cancer and its associations with estrogen receptor (ER)-β expression and clinical outcomes

Characteristics Total patients Nav1.5 low expression Nav1.5 high expression P value
Clinical parameter
 Gender     0.384
  Male 145 (53.9) 18 (12.4) 127 (87.6)  
  Female 124 (46.1) 20 (16.1) 104 (83.9)  
 Age (years)
  ≤ 60 136 (50.6) 21 (15.4) 115 (84.6) 0.532
  > 60 133 (49.4) 17 (12.8) 116 (87.2)  
 Tumor localization     0.503
  Right-sided colon 98 (36.4) 12 (12.2) 86 (87.8)  
  Left-sided colon 171 (63.6) 26 (15.2) 145 (84.8)  
 Preoperative serum CEA (ng/mL)a     0.011
  ≤ 5 154 (62.6) 29 (18.8) 125 (81.2)  
  > 5 92 (37.4) 6 (6.5) 86 (93.5)  
 Preoperative serum CA199 (U/mL)b     0.947
  ≤ 35 180 (81.1) 25 (13.9) 155 (86.1)  
  > 35 42 (18.9) 6 (14.3) 36 (85.7)  
 Adjuvant chemotherapy     0.556
  Yes 228 (84.8) 31 (81.6) 197 (85.3)  
  No 41 (15.2) 7 (18.4) 34 (14.7)  
Pathologic feature
 Tumor size (cm)     0.863
  ≤ 5 138 (51.3) 19 (13.8) 119 (86.2)  
  > 5 131 (48.7) 19 (14.5) 112 (85.5)  
 Tumor differentiation     0.983
  Well and moderate 248 (92.2) 35 (14.1) 213 (85.9)  
  Poor 21 (7.8) 3 (14.3) 18 (85.7)  
 T category     0.385
  T1 17 (6.3) 8 (47.1) 9 (52.9)  
  T2 50 (18.6) 4 (8.0) 46 (92.0)  
  T3 108 (40.1) 9 (8.3) 99 (91.7)  
  T4 94 (34.9) 17 (18.1) 77 (81.9)  
 N category     0.545
  N0 195 (72.5) 26 (13.3) 169 (86.7)  
  N1-2 74 (27.5) 12 (16.2) 62 (83.8)  
 TNM stage     0.836
  I 61 (22.7) 11 (18.0) 50 (82.0)  
  II 134 (49.8) 15 (11.2) 119 (88.8)  
  III 74 (27.5) 12 (16.2) 62 (83.8)  
 ER-β statusc     0.024
  Low expression 51 (19.8) 12 (23.5) 39 (76.5)  
  High expression 206 (80.2) 23 (11.2) 183 (88.8)  
  1. All data are presented as number of patients followed by percentage in the parentheses
  2. ER-β estrogen receptor-β, TNM tumor-node-metastasis, CEA carcinoembryonic antigen, CA199 cancer antigen (CA) 199
  3. aThe data of preoperative CEA level were available in 246 patients
  4. bThe data of preoperative CA199 level were available in 222 patients
  5. cER-β status was evaluated in 257 patients