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Table 2 Cox proportional hazards regression analyses of cancer-specific survival at the time of diagnosis and cancer-specific conditional survival for gallbladder cancer survivors at 1, 3, and 5 years after diagnosis

From: Conditional survival in patients with gallbladder cancer

Characteristics At diagnosis (n = 9760) 1 year after diagnosis (n = 3232) 3 years after diagnosis (n = 1178) 5 years after diagnosis (n = 612)
Patients CSD HR (95% CI) P value Survivors CSCD HR (95% CI) P value Survivors CSCD HR (95% CI) P value Survivors CSCD HR (95% CI) P value
Age at diagnosis (years)
 < 65 3056 1760 (57.6) Reference   1223 477 (39.0) Reference   470 63 (13.4) Reference   251 15 (6.0) Reference  
 65–79 3975 2177 (54.8) 1.178 (1.104–1.256) < 0.001 1339 472 (35.3) 1.038 (0.912–1.182) 0.574 493 71 (14.4) 1.117 (0.789–1.581) 0.534 261 15 (5.7) 0.971 (0.472–1.998) 0.937
 ≥ 80 2729 1495 (54.8) 1.584 (1.471–1.706) < 0.001 670 213 (31.8) 1.271 (1.068–1.513) 0.007 215 32 (14.9) 1.504 (0.967–2.338) 0.070 100 4 (4.0) 0.885 (0.290–2.698) 0.830
Sex
 Men 3012 1633 (54.2) Reference   956 349 (36.5) NA   320 47 (14.7) NA   158 11 (7.0) NA  
 Women 6748 3799 (56.3) 0.988 (0.931–1.049) 0.689 2276 813 (35.7)    858 119 (13.9)    454 23 (5.1)   
Race
 White 7528 4148 (55.1) Reference   2506 886 (35.4) Reference   908 134 (14.8) Reference   473 28 (5.9) NA  
 Black 1163 683 (58.7) 1.095 (1.009–1.189) 0.030 370 151 (40.8) 1.202 (1.009–1.432) 0.040 128 15 (11.7) 0.782 (0.455–1.346) 0.375 64 5 (7.8)   
 Others 1040 596 (57.3) 0.997 (0.914–1.087) 0.945 347 125 (36.0) 1.005 (0.831–1.215) 0.958 139 17 (12.2) 0.861 (0.515–1.441) 0.569 73 1 (1.4)   
 Unknown 29 5 (17.2) 0.374 (0.156–0.900) 0.028 9 0 (0.0) NA (NA) 0.873 3 0 (0.0) NA (NA) 0.970 2 0 (0.0)   
Histology
 Non-papillary 9415 5343 (56.7) Reference   3007 1120 (37.2) Reference   1059 156 (14.7) Reference   547 33 (6.0) NA  
 Papillary 345 89 (25.8) 0.550 (0.444–0.680) < 0.001 225 42 (18.7) 0.622 (0.454–0.851) 0.003 119 10 (8.4) 0.792 (0.411–1.527) 0.486 65 1 (1.5)   
Grade
 Grade 1–2 3648 1549 (42.5) Reference   1821 580 (31.9) Reference   716 105 (14.7) Reference   372 25 (6.7) NA  
 Grade 3–4 2874 1760 (61.2) 1.523 (1.419–1.634) < 0.001 790 353 (44.7) 1.152 (1.004–1.322) 0.043 243 40 (16.5) 0.744 (0.506–1.093) 0.132 121 6 (5.0)   
 Unknown 3238 2123 (65.6) 1.144 (1.052–1.244) 0.002 621 229 (36.9) 0.776 (0.639–0.942) 0.010 219 21 (9.6) 0.703 (0.409–1.206) 0.200 119 3 (2.5)   
T category
 T1 1520 525 (34.5) Reference   817 160 (19.6) Reference   433 34 (7.9) Reference   257 9 (3.5) Reference  
 T2 2354 870 (37.0) 1.153 (1.032–1.289) 0.012 1276 361 (28.3) 1.358 (1.118–1.649) < 0.002 504 61 (12.1) 1.446 (0.931–2.247) 0.101 241 12 (5.0) 1.346 (0.567–3.199) 0.501
 T3–4 4492 3033 (67.5) 2.356 (2.133–2.602) < 0.001 979 551 (56.3) 2.916 (2.405–3.537) < 0.001 212 62 (29.2) 3.948 (2.486–6.270) < 0.001 99 13 (13.1) 3.388 (1.400–8.196) 0.007
 Unknown 1394 1004 (72.0) 1.897 (1.676–2.148) < 0.001 160 90 (56.3) 2.629 (1.913–3.613) < 0.001 29 9 (31.0) 7.250 (2.871–18.309) < 0.001 15 0 (0.0) NA (NA) 0.980
N category
 N0 5521 2601 (47.1) Reference   2220 646 (29.1) Reference   927 114 (12.3) Reference   495 20 (4.0) NA  
 N1–2 2623 1683 (64.2) 1.213 (1.137–1.294) < 0.001 786 407 (51.8) 1.493 (1.301–1.714) < 0.001 188 41 (21.8) 1.272 (0.845–1.915) 0.248 82 12 (14.6)   
 Unknown 1616 1148 (71.0) 1.277 (1.173–1.392) < 0.001 226 109 (48.2) 1.230 (0.947–1.598) 0.120 63 11 (17.5) 1.088 (0.429–2.763) 0.858 35 2 (5.7)   
M category
 M0 5594 2427 (43.4) Reference   2665 831 (31.2) Reference   1085 143 (13.2) Reference   568 30 (5.3) Reference  
 M1 3266 2385 (73.0) 2.050 (1.912–2.199) < 0.001 408 258 (63.2) 2.346 (1.987–2.769) < 0.001 40 12 (30.0) 2.022 (1.040–3.932) 0.038 16 4 (25.0) 4.620 (1.476–14.457) 0.009
 Unknown 900 620 (68.9) 1.417 (1.274–1.575) < 0.001 159 73 (45.9) 1.051 (0.784–1.409) 0.741 53 11 (20.8) 1.093 (0.447–2.675) 0.845 28 0 (0.0) NA (NA) 0.976
Surgery
 No 3393 2427 (71.5) Reference   348 190 (54.6) Reference   55 4 (7.3) Reference   32 1 (3.1) Reference  
 Yes 6321 2970 (47.0) 0.576 (0.532–0.624) < 0.001 2873 968 (33.7) 0.754 (0.605–0.940) 0.012 1119 162 (14.5) 4.403 (1.466–13.219) 0.008 578 33 (5.7) 3.000 (0.372–24.190) 0.302
 Unknown 46 35 (76.1) 0.980 (0.684–1.404) 0.913 11 4 (36.4) 0.841 (0.299–2.365) 0.742 4 0 (0.0) NA (NA) 0.969 2 0 (0.0) NA (NA) 0.994
Radiotherapy
 No 8329 4694 (56.4) Reference   2483 829 (33.4) Reference   949 120 (12.6) Reference   505 25 (5.0) NA  
 Yes 1254 641 (51.1) 0.740 (0.679–0.808) < 0.001 687 314 (45.7) 1.195 (1.035–1.379) 0.015 215 45 (20.9) 1.378 (0.933–2.035) 0.107 100 9 (9.0)   
 Unknown 177 97 (54.8) 0.876 (0.707–1.085) 0.225 62 19 (30.6) 0.897 (0.558–1.441) 0.653 14 1 (7.1) 0.583 (0.080–4.233) 0.594 7 0 (0.0)   
Insurance
 No 1484 804 (54.2) Reference   436 135 (31.0) Reference   134 13 (9.7) NA   47 0 (0.0) NA  
 Yes 5311 2766 (52.1) 0.891 (0.822–0.966) 0.005 1769 586 (33.1) 1.049 (0.867–1.269) 0.625 547 53 (9.7)    204 9 (4.4)   
 Unknown 2965 1862 (62.8) 1.061 (0.975–1.155) 0.170 1027 441 (42.9) 1.154 (0.948–1.405) 0.154 497 100 (20.1)    361 25 (6.9)   
Marriage
 No 4610 2603 (56.5) Reference   1365 454 (33.3) Reference   480 70 (14.6) NA   237 15 (6.3) NA  
 Yes 4689 2591 (55.3) 0.904 (0.852–0.958) 0.001 1723 662 (38.4) 1.093 (0.965–1.239) 0.163 651 91 (14.0)    346 19 (5.5)   
 Unknown 461 238 (51.6) 0.905 (0.792–1.035) 0.144 144 46 (31.9) 1.011 (0.746–1.371) 0.942 47 5 (10.6)    29 0 (0.0)   
  1. Patients at the time of diagnosis and survivors at 1, 3, and 5 years after diagnosis are presented as number of cases. CSD and CSCD are presented as number of cases followed by percentage in parentheses
  2. CSD cancer-specific death, CSCD cancer-specific conditional death, HR hazard ratio, CI confidence interval, NA not applicable