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Table 5 Multivariate analysis of overall survival and cancer-specific survival using Cox proportion hazards modeling

From: The influence of stage at diagnosis and molecular subtype on breast cancer patient survival: a hospital-based multi-center study

Characteristic

OS

CSS

HRa (95% CI)

P valuea

HRa (95% CI)

P valuea

Age

1.03 (1.02–1.05)

< 0.01

1.03 (1.01–1.04)

0.01

BMI

1.03 (1.01–1.06)

0.02

1.02 (0.99–1.05)

0.14

Menopausal status

 Premenopausal

1.00

 

1.00

 

 Postmenopausal

0.80 (0.59–1.09)

0.16

0.81 (0.58–1.12)

0.21

Histological grade

 Well differentiated

1.00

 

1.00

 

 Moderately differentiated

1.60 (0.94–2.71)

0.08

1.50 (0.87–2.59)

0.14

 Poorly differentiated

2.14 (1.24–3.70)

0.01

2.02 (1.15–3.55)

0.02

Histological type

 Ductal

1.00

 

1.00

 

 Lobular

0.91 (0.33–2.46)

0.85

0.77 (0.24–2.44)

0.66

 Others

0.94 (0.56–1.59)

0.83

0.85 (0.48–1.52)

0.59

Stage

 I

1.00

 

1.00

 

 II

2.19 (1.57–3.06)

< 0.01

2.24 (1.56–3.22)

<0.01

 III

6.24 (4.40–8.87)

< 0.01

6.89 (4.72–10.05)

<0.01

 IV

25.77 (16.36–40.59)

< 0.01

29.48 (18.33–47.44)

<0.01

Molecular subtype

 Luminal A

1.00

 

1.00

 

 Luminal B

1.26 (0.93–1.72)

0.14

1.31 (0.95–1.80)

0.10

 HER2

1.50 (1.08–2.09)

0.02

1.47 (1.03–2.09)

0.03

 Triple-negative

1.83 (1.37–2.43)

< 0.01

1.89 (1.39–2.55)

< 0.01

  1. aHRs, 95% CIs, and P values were calculated using the adjusted multivariate Cox proportional hazard model
  2. OS overall survival, CSS cancer-specific survival, HR hazard ratio, CI confidence interval, BMI body mass index