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Table 5 Multivariate analysis of overall survival and cancer-specific survival using Cox proportion hazards modeling

From: The influence of stage at diagnosis and molecular subtype on breast cancer patient survival: a hospital-based multi-center study

Characteristic OS CSS
HRa (95% CI) P valuea HRa (95% CI) P valuea
Age 1.03 (1.02–1.05) < 0.01 1.03 (1.01–1.04) 0.01
BMI 1.03 (1.01–1.06) 0.02 1.02 (0.99–1.05) 0.14
Menopausal status
 Premenopausal 1.00   1.00  
 Postmenopausal 0.80 (0.59–1.09) 0.16 0.81 (0.58–1.12) 0.21
Histological grade
 Well differentiated 1.00   1.00  
 Moderately differentiated 1.60 (0.94–2.71) 0.08 1.50 (0.87–2.59) 0.14
 Poorly differentiated 2.14 (1.24–3.70) 0.01 2.02 (1.15–3.55) 0.02
Histological type
 Ductal 1.00   1.00  
 Lobular 0.91 (0.33–2.46) 0.85 0.77 (0.24–2.44) 0.66
 Others 0.94 (0.56–1.59) 0.83 0.85 (0.48–1.52) 0.59
Stage
 I 1.00   1.00  
 II 2.19 (1.57–3.06) < 0.01 2.24 (1.56–3.22) <0.01
 III 6.24 (4.40–8.87) < 0.01 6.89 (4.72–10.05) <0.01
 IV 25.77 (16.36–40.59) < 0.01 29.48 (18.33–47.44) <0.01
Molecular subtype
 Luminal A 1.00   1.00  
 Luminal B 1.26 (0.93–1.72) 0.14 1.31 (0.95–1.80) 0.10
 HER2 1.50 (1.08–2.09) 0.02 1.47 (1.03–2.09) 0.03
 Triple-negative 1.83 (1.37–2.43) < 0.01 1.89 (1.39–2.55) < 0.01
  1. aHRs, 95% CIs, and P values were calculated using the adjusted multivariate Cox proportional hazard model
  2. OS overall survival, CSS cancer-specific survival, HR hazard ratio, CI confidence interval, BMI body mass index