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Table 1 Relationships between CXCR4, CXCL12, and Cyclin D1 expression levels and clinicopathologic characteristics of sporadic MPNST patients

From: The prognostic value of C-X-C motif chemokine receptor 4 in patients with sporadic malignant peripheral nerve sheath tumors

Clinical characteristic Total (cases) CXCR4 expression [cases (%)] CXCL12 expression [cases (%)] Cyclin D1 expression [cases (%)]
High Low χ2 P High Low χ2 P High Low χ2 P
Sex     0.420 0.517    1.008 0.315    2.259 0.133
 Male 31 9 (29.0) 22 (71.0)    19 (61.3) 12 (39.7)    6 (19.4) 25 (80.6)   
 Female 27 10 (37.0) 17 (63.0)   13 (48.1) 14 (51.9)   10 (37.0) 17 (63.0)  
Age (years)     0.105 0.745    1.277 0.258    0.840 0.359
 ≥ 40 38 13 (34.2) 25 (65.8)    23 (60.5) 15 (39.5)    9 (23.7) 29 (76.3)   
 < 40 20 6 (30.0) 14 (70.0)   9 (45.0) 11 (55.0)   7 (35.0) 13 (65.0)  
Tumor site     2.105 0.349    0.512 0.774    1.045 0.593
 Head/neck 10 3 (30.0) 7 (70.0)    5 (50.0) 5 (50.0)    2 (20.0) 8 (80.0)   
 Trunk 23 10 (43.5) 13 (56.5)   14 (60.9) 9 (39.1)   8 (37.8) 15 (62.2)  
 Extremity 25 6 (24.0) 19 (76.0)   13 (52.0) 12 (48.0)   6 (24.0) 19 (76.0)  
Tumor size (cm)a     < 0.001 1.000    1.612 0.447    0.397 0.820
 < 5 21 7 (30.0) 14 (70.0)    14 (70.0) 7 (30.0)    5 (23.8) 16 (76.2)   
 5–10 21 7 (30.0) 14 (70.0)   11 (52.4) 10 (47.6)   6 (28.6) 15 (71.4)  
 > 10 15 5 (33.3) 10 (66.7)   7 (46.7) 8 (53.3)   5 (33.3) 10 (66.7)  
AJCC stageb     2.400 0.494    1.679 0.642    2.484 0.478
 I 6 1 (16.7) 5 (83.3)    3 (50.0) 3 (50.0)    2 (33.3) 4 (66.7)   
 II 32 13 (40.6) 19 (59.4)   20 (62.5) 12 (37.5)   9 (28.1) 23 (71.9)  
 III 7 2 (28.6) 5 (71.4)   4 (57.1) 3 (42.9)   3 (42.9) 4 (57.1)  
 IV 10 2 (20.0) 8 (80.0)   4 (40.0) 6 (60.0)   1 (10.0) 9 (90.0)  
Radiotherapyc     0.196 0.658    0.252 0.615    0.163 0.686
 Yes 21 6 (28.6) 15 (71.4)    11 (52.4) 10 (47.6)    7 (33.3) 14 (66.7)   
 No 32 11 (34.3) 21 (65.7)   19 (59.4) 13 (40.6)   9 (28.1) 23 (71.9)  
Chemotherapyd     0.994 0.319    0.065 0.799    0.152 0.697
 Yes 22 5 (22.7) 17 (77.3)    12 (54.5) 10 (45.5)    6 (27.3) 16 (72.7)   
 No 31 11 (35.5) 20 (64.5)   18 (58.1) 13 (41.9)   10 (32.3) 21 (67.7)  
Surgery type     1.069 0.301    4.416 0.036    1.569 0.210
 Wide resection 36 10 (27.8) 26 (72.2)    16 (44.4) 20 (55.6)    12 (33.3) 24 (66.7)   
 Marginal resection 22 9 (40.9) 13 (59.1)   16 (72.7) 6 (27.3)   4 (18.2) 18 (81.8)  
Recurrence     1.046 0.306    1.384 0.239    0.429 0.513
 Yes 33 9 (27.3) 24 (72.7)    16 (48.5) 17 (51.5)    8 (24.2) 25 (75.8)   
 No 25 10 (40.0) 15 (60.0)   16 (64.0) 9 (36.0)   8 (32.0) 17 (68.0)  
Metastasis     0.834 0.361    1.277 0.258    0.840 0.359
 Yes 20 5 (25.0) 15 (75.0)    9 (45.00) 11 (55.0)    7 (35.0) 13 (75.0)   
 No 38 14 (36.8) 24 (63.2)   23 (60.5) 15 (39.5)   9 (23.7) 29 (76.3)  
  1. MPNST malignant peripheral nerve sheath tumor, CXCR4 C-X-C motif chemokine receptor 4, CXCL12 C-X-C motif chemokine ligand 12, AJCC American Joint Committee on Cancer
  2. aTumor size information is missing for 1 patient
  3. bAJCC stage information is missing for 3 patients
  4. cRadiotherapy information is missing for 5 patients
  5. dChemotherapy information is missing for 5 patients