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Table 3 Univariate and multivariate analyses of clinicopathologic factors and SII for OS of patients with gastric cancer

From: Prognostic value of systemic immune-inflammation index in patients with gastric cancer

Variable Univariate analysis Multivariate analysis
HR (95% CI) P value HR (95% CI) P value
Sex 0.904 (0.707–1.155) 0.420   NI
Age 1.301 (1.027–1.647) 0.029 1.356 (1.059–1.735) 0.026
Tumor location 0.766 (0.672–0.873) <0.001 0.874 (0.762–1.003) 0.056
Tumor size 2.421 (1.897–3.092) <0.001 1.290 (0.997–1.670) 0.017
Pathologic type 0.984 (0.886–1.092) 0.758   NI
Borrmann classification 1.790 (1.524–2.103) <0.001 1.521 (1.279–1.810) <0.001
TNM stage 2.428 (2.087–2.825) <0.001 2.081 (1.772–2.443) <0.001
CEA 1.844 (1.303–2.609) 0.001 1.431 (1.006–2.035) 0.027
NLR 1.581 (1.250–2.001) <0.001 0.902 (0.637–1.278) 0.563
PLR 1.738 (1.332–2.267) <0.001 1.272 (0.902–1.794) 0.170
SII 1.848 (1.455–2.348) <0.001 1.551 (1.211–1.987) 0.015
  1. HR, hazard ratio; NI, not included; OS, overall survival; CI, confidence interval; CEA, carcinoembryonic antigen; NLR, neutrophil–lymphocyte ratio; PLR, platelet–lymphocyte ratio; SII, systemic immune-inflammation index