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Table 5 Prognostic markers involved in regulating angiogenesis in ESCC as reported in original studies

From: Immunohistochemical prognostic markers of esophageal squamous cell carcinoma: a systematic review

Marker References Sample size Clinical stage OS DFS Analytic methods
HR 95% CI P value HR 95% CI P value
VEGF Tao et al. [15] 90 0.027 0.009–0.079 <0.001 Cox proportional hazards model
Huang et al. [52] 106 I–IV 1.214 0.639–2.305 0.554 Cox proportional hazards model
Hou et al. [72] 483 I–III 1.864 1.055–3.294 0.032 2.077 1.265–3.411 <0.01 Cox proportional hazards model
Omoto et al. [73] 119 1.237 0.919–1.649 0.157 Cox proportional hazards model
HIF-1α Shirakawa et al. [76] 229 I–IV >0.05 Log-rank test
Zhang et al. [77] 136 I–IV 1.297 0.856–1.964 0.220 1.234 0.794–1.920 0.350 Cox proportional hazards model
  1. ESCC esophageal squamous cell carcinoma, VEGF vascular endothelial growth factor, HIF-1α hypoxia-inducible factor-1α, OS overall survival, DFS disease-free survival, HR hazard ratio, CI confidence interval, – no data