From: Immunohistochemical prognostic markers of esophageal squamous cell carcinoma: a systematic review

Marker | References | Sample size | Clinical stage | OS | DFS | Analytic methods | ||||
---|---|---|---|---|---|---|---|---|---|---|

HR | 95% CI |
P value
| HR | 95% CI |
P value
| |||||

VEGF | Tao et al. [15] | 90 | – | 0.027 | 0.009–0.079 | <0.001 | – | – | – | Cox proportional hazards model |

Huang et al. [52] | 106 | I–IV | 1.214 | 0.639–2.305 | 0.554 | – | – | – | Cox proportional hazards model | |

Hou et al. [72] | 483 | I–III | 1.864 | 1.055–3.294 | 0.032 | 2.077 | 1.265–3.411 | <0.01 | Cox proportional hazards model | |

Omoto et al. [73] | 119 | – | 1.237 | 0.919–1.649 | 0.157 | – | – | – | Cox proportional hazards model | |

HIF-1α | Shirakawa et al. [76] | 229 | I–IV | – | – | >0.05 | – | – | – | Log-rank test |

Zhang et al. [77] | 136 | I–IV | 1.297 | 0.856–1.964 | 0.220 | 1.234 | 0.794–1.920 | 0.350 | Cox proportional hazards model |