Immunohistochemical prognostic markers of esophageal squamous cell carcinoma: a systematic review

Cancer Communications

Table 5 Prognostic markers involved in regulating angiogenesis in ESCC as reported in original studies

Marker	References	Sample size	Clinical stage	OS			DFS			Analytic methods
Marker	References	Sample size	Clinical stage	HR	95% CI	P value	HR	95% CI	P value	Analytic methods
VEGF	Tao et al. [15]	90	–	0.027	0.009–0.079	<0.001	–	–	–	Cox proportional hazards model
	Huang et al. [52]	106	I–IV	1.214	0.639–2.305	0.554	–	–	–	Cox proportional hazards model
	Hou et al. [72]	483	I–III	1.864	1.055–3.294	0.032	2.077	1.265–3.411	<0.01	Cox proportional hazards model
	Omoto et al. [73]	119	–	1.237	0.919–1.649	0.157	–	–	–	Cox proportional hazards model
HIF-1α	Shirakawa et al. [76]	229	I–IV	–	–	>0.05	–	–	–	Log-rank test
HIF-1α	Zhang et al. [77]	136	I–IV	1.297	0.856–1.964	0.220	1.234	0.794–1.920	0.350	Cox proportional hazards model

ESCC esophageal squamous cell carcinoma, VEGF vascular endothelial growth factor, HIF-1α hypoxia-inducible factor-1α, OS overall survival, DFS disease-free survival, HR hazard ratio, CI confidence interval, – no data

ISSN: 2523-3548