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Table 4 Prognostic markers involved in regulating cell apoptosis in ESCC as reported in original studies

From: Immunohistochemical prognostic markers of esophageal squamous cell carcinoma: a systematic review

Marker References Sample size Clinical stage OS DFS Analytic methods
HR 95% CI P value HR 95% CI P value
MDM2 Mathew et al. [11] 50 I–IV >0.05 Log-rank test
Okamoto et al. [20] 86 I–IV 0.31 0.61 Log-rank test
Nam et al. [49] 51 I–IV >0.05 Log-rank test
Ikeguchi et al. [55] 107 I–IV 2.017 1.098–3.703 0.024 Cox proportional hazards model
Sun et al. [56] 149 I–IV 1.698 1.054– 0.03 Cox proportional hazards model
Cheng et al. [57] 119 I–IV 0.168 0.533–1.509 0.682 Cox proportional hazards model
Fas Chan et al. [60] 58 I–IV 0.639 0.442–0.925 <0.05 Cox proportional hazards model
Shibakita et al. [61] 106 I–IV 3.26 1.32–8.07 0.0103 Cox proportional hazards model
Chang et al. [62] 118 I–IV >0.05 Log-rank test
Takikita et al. [63] 313 I–IV 0.79 0.49–1.27 0.32 Cox proportional hazards model
Bax Ikeguchi et al. [13] 141 I–IV >0.05 Cox proportional hazards model
Guner et al. [45] 53 I–IV 0.474 0.238–0.941 0.0328 Cox proportional hazards model
Chang et al. [62] 118 I–IV >0.05 Cox proportional hazards model
Sturm et al. [64] 53 I–IV 0.435 0.242–0.862 0.016 Cox proportional hazards model
Kurabayashi et al. [65] 76 I–IV <0.05 Log-rank test
Natsugoe et al. [66] 111 II–IV >0.05 Log-rank test
Takayama et al. [67] 86 I–IV 0.954 0.517–1.763 0.881 Cox proportional hazards model
Matsumoto et al. [68] 79 >0.05 Cox proportional hazards model
Sarbia et al. [69] 172 I–IV >0.05 Log-rank test
Bcl-2 Guner et al. [45] 53 I–IV 1.280 0.688–2.382 0.4364 Cox proportional hazards model (univariate)
Chang et al. [62] 118 I–IV 0.529 0.387–0.978 0.042 Cox proportional hazards model
Takikita et al. [63] 313 I–IV 1.29 0.52–3.25 0.58 Cox proportional hazards model
Kurabayashi et al. [65] 76 I–IV >0.05 Log-rank test
Takayama et al. [67] 86 I–IV 1.506 0728–3.115 0.269 Cox proportional hazards model
Bcl-x Natsugoe et al. [66] 111 II–IV >0.05 Log-rank test
Takayama et al. [67] 86 I–IV 2.441 1.139–5.232 0.022 Cox proportional hazards model
Matsumoto et al. [68] 79 0.194 Cox proportional hazards model
Torzewski et al. [70] 172 I–IV >0.05 Cox proportional hazards model
Caspase-3 Jiang et al. [14] 64 I–III 0.007 Cox proportional hazards model
Wang et al. [21] 122 0.584 0.370–0.921 0.021 Cox proportional hazards model
Chang et al. [62] 118 I–IV >0.05 Cox proportional hazards model
Kurabayashi et al. [65] 76 I–IV >0.05 Log-rank test
  1. No original studies on the prognostic significance of Survivin in ESCC were reported after the meta-analyses. Therefore, Survivin is not listed
  2. ESCC esophageal squamous cell carcinoma, MDM2 murine double minute gene 2, OS overall survival, DFS disease-free survival, HR hazard ratio, CI confidence interval, no data