Table 2 Prognostic markers involved in regulating proliferation in ESCC as reported in original studies
From: Immunohistochemical prognostic markers of esophageal squamous cell carcinoma: a systematic review
Marker | References | Sample size | Clinical stage | OS | DFS | Analytic methods | ||||
|---|---|---|---|---|---|---|---|---|---|---|
HR | 95% CI | P value | HR | 95% CI | P value | |||||
EGFR | Zhang et al. [10] | 441 | IB-IIIC | 1.452 | 1.137–1.855 | 0.003 | 1.351 | 1.057–1.728 | 0.016 | Cox proportional hazards model |
Zhang et al. [19] | 128 | II–IV | – | – | >0.05 | – | – | – | Log-rank test | |
Cao et al. [29] | 315 | I–IV | 1.614 | 1.027–2.536 | 0.038 | – | – | – | Cox proportional hazards model (univariate) | |
Shang et al. [30] | 590 | I-III | 2.652 | 1.708-4.118 | 0.00001 | – | – | – | Cox proportional hazards model | |
Jiang et al. [31] | 96 | – | – | – | 0.007 | – | – | 0.006 | Log-rank test | |
Xu et al. [32] | 87 | I–III | 1.728 | 1.011–2.955 | 0.046 | – | – | – | Cox proportional hazards model | |
HER2 | Zhang et al. [19] | 128 | II–IV | – | – | >0.05 | – | – | – | Log-rank test |
Mimura et al. [33] | 66 | 0–IV | 0.92 | 0.35–2.41 | 0.861 | – | – | – | Cox proportional hazards model, | |
Sunpaweravong et al. [34] | 55 | II–IV | – | – | 0.04 | – | – | – | Log-rank test | |
Zhan et al. [35] | 145 | I–IV | – | – | 0.036 | – | – | – | Log-rank test | |
p-mTOR | Hirashima et al. [36] | 143 | I–III | 2.92 | 1.48–5.78 | 0.002 | – | – | – | Cox proportional hazards model |
Kim et al. [37] | 165 | I–IV | 1.47 | 0.92-2.35 | 0.104 | 1.67 | 1.07–2.62 | 0.025 | Cox proportional hazards model | |
Li et al. [38] | 105 | I–IV | – | – | 0.022 | – | – | 0.014 | Log-rank test | |
Li et al. [39] | 77 | II–III | 2.814 | 1.553–5.097 | 0.001 | 2.438 | 1.368–4.347 | 0.003 | Cox proportional hazards model | |
P16 | Mathew et al. [11] | 50 | I–IV | – | – | >0.05 | – | – | – | Log-rank test |
Okamoto et al. [20] | 86 | I–IV | – | – | 0.19 | – | – | 0.14 | Cox proportional hazards model (univariate) | |
Cao et al. [42] | 105 | I–III | 4.23 | 1.75–8.54 | 0.03 | 2.52 | 1.12–5.71 | 0.02 | Cox proportional hazards model | |
Guan et al. [43] | 90 | I–IV | 0.234 | 0.086–0.637 | 0.004 | – | – | – | Cox proportional hazards model | |
Takeuchi et al. [44] | 90 | I–III | 0.312 | – | 0.003 | – | – | – | Cox proportional hazards model | |
Guner et al. [45] | 53 | I–III | 0.410 | 0.203–0.828 | 0.013 | – | – | – | Cox proportional hazards model (univariate) | |
Fujiwara et al. [46] | 60 | I–IV | 0.597 | 0.287–1.032 | 0.067 | – | – | – | Cox proportional hazards model | |
P21 | Shiozaki et al. [12] | 69 | I–IV | 0.381 | 0.123–0.995 | 0.049 | – | – | – | Cox proportional hazards model |