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Table 2 Primary treatment modalities and responses in patients with ENKTL

From: Prognostic role of ABO blood type in patients with extranodal natural killer/T cell lymphoma, nasal type: a triple-center study

Characteristic

Total (cases)

Blood four-type group [cases (%)]

P

Blood two-type group [cases (%)]

P

O

A

B

AB

O

Non-O

Treatment modality

     

0.701

  

0.690

 CT combined RT

436

164 (64.3)

118 (60.5)

120 (63.8)

34 (57.6)

 

164 (64.3)

272 (61.5)

 

 CT alone

171

57 (22.4)

49 (25.1)

47 (25.0)

18 (30.5)

 

57 (22.4)

114 (25.8)

 

 RT alone

72

26 (10.2)

23 (11.8)

16 (8.5)

7 (11.9)

 

26 (10.2)

46 (10.4)

 

 Best supportive care

18

8 (3.1)

5 (2.6)

5 (2.7)

0 (0)

 

8 (3.1)

10 (2.3)

 

CT regimen

     

0.675

  

0.534

 CHOP or CHOP-like

218

73 (28.6)

68 (34.9)

61 (32.4)

16 (27.1)

 

73 (28.6)

145 (32.8)

 

 EPOCH

105

43 (16.9)

24 (12.3)

32 (17.0)

6 (10.2)

 

43 (16.9)

62 (14.0)

 

 ATT

43

15 (5.9)

13 (6.7)

12 (6.4)

3 (5.1)

 

15 (5.9)

28 (6.3)

 

 GEMOX + L-asp

232

85 (33.3)

61 (31.3)

60 (31.9)

26 (44.1)

 

85 (33.3)

147 (33.3)

 

 SMILE

9

5 (2.0)

1 (0.4)

2 (1.1)

1 (0.4)

 

5 (2.0)

4 (0.9)

 

Complete response

509

202 (79.2)

133 (68.2)

131 (69.7)

43 (72.9)

0.040

202 (79.2)

307 (69.5)

0.005

  1. CT chemotherapy, RT radiotherapy, CHOP cyclophosphamide + doxorubicin + vincristine + prednisone, EPOCH etoposide + doxorubicin + vincristine + cyclophosphamide + prednisone, ATT alternating triple therapy (CHOP-B, cyclophosphamide + doxorubicin + vincristine + bleomycin + prednisone, IMVP-16 ifosfamide + methotrexate + etoposide; DHAP, dexamethasone + cisplatin + cytarabine), GEMOX + L-asp gemcitabine + oxaliplatin + l-asparaginase, SMILE dexamethasone + methotrexate + ifosfamide + l-asparaginase + etoposide