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Table 5 Multivariate analysis of prognostic factors for disease-free survival and overall survival of patients with gastric adenocarcinoma

From: Prognostic value of programmed death-1, programmed death-ligand 1, programmed death-ligand 2 expression, and CD8(+) T cell density in primary tumors and metastatic lymph nodes from patients with stage T1-4N+M0 gastric adenocarcinoma

Variable Disease-free survival Variable Overall survival
HR 95% CI P HR 95% CI P
T stage    <0.001 T stage    <0.001
 T1–T2 1.000        T1–T2 1.000   
 T3–T4 4.475 2.084–9.610       T3–T4 4.736 2.116–10.599  
Tumor location    0.005 Tumor location    0.002
 Cardia 1.000        Cardia 1.000   
 Body 1.327 0.691–2.547       Body 2.500 1.234–5.064  
 Antrum 0.498 0.295–0.840       Antrum 0.671 0.394–1.143  
PD-L1 expression in primary tumors    0.025 Neural invasion    0.008
 Negative 1.000        Negative 1.000   
 Positive 1.735 1.073–2.807       Positive 2.172 1.220–3.459  
Density of CD8(+) T cells in primary tumors    0.009 PD-L2 expression in primary tumors    0.003
 Low 1.000        Negative 1.000   
 High 0.519 0.318–0.847       Positive 2.362 1.342–4.157  
PD-1 expression on CD8(+) T cells in primary tumors    0.014 Density of CD8(+) T cells in primary tumors    0.004
 Negative 1.000        Low 1.000   
 Positive 1.833 1.131–2.972       High 0.460 0.272–0.780  
PD-L2 expression in metastatic lymph nodes    0.033 PD-1 expression on CD8(+) T cells in primary tumors    0.006
 Negative 1.000        Negative 1.000   
 Positive 1.785 1.047–3.043       Positive 2.079 1.239–3.489  
     PD-L1 expression in metastatic lymph nodes    0.003
         Negative 1.000   
         Positive 2.198 1.301–3.712  
  1. HR hazard ratio, CI confidence interval