Prognostic value of programmed death-1, programmed death-ligand 1, programmed death-ligand 2 expression, and CD8(+) T cell density in primary tumors and metastatic lymph nodes from patients with stage T1-4N+M0 gastric adenocarcinoma

Table 5 Multivariate analysis of prognostic factors for disease-free survival and overall survival of patients with gastric adenocarcinoma

Variable	Disease-free survival			Variable	Overall survival
Variable	HR	95% CI	P	Variable	HR	95% CI	P
T stage			<0.001	T stage			<0.001
T1–T2	1.000			T1–T2	1.000
T3–T4	4.475	2.084–9.610		T3–T4	4.736	2.116–10.599
Tumor location			0.005	Tumor location			0.002
Cardia	1.000			Cardia	1.000
Body	1.327	0.691–2.547		Body	2.500	1.234–5.064
Antrum	0.498	0.295–0.840		Antrum	0.671	0.394–1.143
PD-L1 expression in primary tumors			0.025	Neural invasion			0.008
Negative	1.000			Negative	1.000
Positive	1.735	1.073–2.807		Positive	2.172	1.220–3.459
Density of CD8(+) T cells in primary tumors			0.009	PD-L2 expression in primary tumors			0.003
Low	1.000			Negative	1.000
High	0.519	0.318–0.847		Positive	2.362	1.342–4.157
PD-1 expression on CD8(+) T cells in primary tumors			0.014	Density of CD8(+) T cells in primary tumors			0.004
Negative	1.000			Low	1.000
Positive	1.833	1.131–2.972		High	0.460	0.272–0.780
PD-L2 expression in metastatic lymph nodes			0.033	PD-1 expression on CD8(+) T cells in primary tumors			0.006
Negative	1.000			Negative	1.000
Positive	1.785	1.047–3.043		Positive	2.079	1.239–3.489
				PD-L1 expression in metastatic lymph nodes			0.003
				Negative	1.000
				Positive	2.198	1.301–3.712

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