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Table 1 Parameter settings in the decision tree for lung cancer screening in urban China

From: Mortality outcomes of low-dose computed tomography screening for lung cancer in urban China: a decision analysis and implications for practice

Variable Definition Base-case analysis (%) Sensitivity analysis (%) Reference source
Lower limit Upper limit
prev Lung cancer prevalence in the screened cohort 0.7666 0.3833 0.8943 Calculated from [18, 22, 26, 32, 53]
CTse Sensitivity of low-dose CT 87.7 71.8 100.0 Meta of [21, 54,55,56,57,58,59,60,61,62,63,64,65,66]
CTsp Specificity of low-dose CT 90.6 86.3 91.1 Meta of [55, 57,58,59,60, 63, 66,67,68,69]
XRse Sensitivity of chest X-ray 65.1 61.4 69.4 Meta of [21, 55,56,57, 60, 62,63,64,65, 70]
XRsp Specificity of chest X-ray 97.5 89.5 98.4 Meta of [55, 57, 60, 63, 69, 71, 72]
CTerl Proportion of early-stage cancera among lung cancers detected with low-dose CT 70.1 63.9 76.0 [73]
XRerl Proportion of early-stage cancera among lung cancers detected with chest X-ray 46.6 38.1 55.0 [73, 74]
NSerl Proportion of early-stage cancersa among lung cancers detected with no screening 27.9 23.2 32.7 Meta of [24, 55, 76,77,78,79 52 d, 75 e, ]
CTidl Proportion of indolent cancersb among lung cancers detected with low-dose CT 25.0 15.0 35.0 [20]
XRidl Proportion of indolent cancersb among lung cancers detected with chest X-ray 20.0 15.0 25.0 [20]
trt_Er Acceptance rate of surgery for early-stage lung cancersa 72.5 68.2 76.0 Meta of [80,81,82]
trt_Ne Acceptance rate of surgery for non-early-stage lung cancersa 28.6 28.2 30.6 Meta of [80,81,82]
srv_Er Survival possibility of individuals with resected early-stage lung cancerc 72.7 62.3 75.7 Meta of [3, 35, 83]
srv_Ne Survival possibility of individuals with resected non-early-stage lung cancerc 39.7 30.2 42.4 Meta of [3, 35, 83]
fpMt Death possibility due to false diagnosis and invasive treatment 0.07 0.00 0.13 [84]
  1. CT computed tomography
  2. aStage I for non-small cell lung cancers and limited stage for small cell lung cancers were defined as early-stage cancers, and others as non-early-stage cancers
  3. bLung cancers such as bronchioloalveolar carcinoma that did not affect survival for a long time if left untreated were defined as indolent cancers
  4. cBased on 5-year estimation
  5. dSeven studies that were conducted among the Chinese population with complete stage information [85,86,87,88,89,90,91] in this meta-analysis were included and reanalyzed in this study
  6. eEight studies with complete stage information [92,93,94,95,96,97,98,99] in this meta-analysis were included and reanalyzed in this study