Table 2 Recent studies on the pro-death role of autophagy in MDR cancer
Intervention for tumor treatment | Cell line | Method(s) to study autophagy | References |
|---|---|---|---|
SAHA | Tamoxifen-resistant MCF-7 | 3-MA | [77] |
Tanshinones | Apoptosis-resistant SW620 | 3-MA | [78] |
Edelfosine lipid nanoparticles | Edelfosine-resistant leukemic K562 | Starvation, staurosporine | [79] |
GMI protein | Multidrug-resistant lung cancer cells | CQ | [80] |
NVP-BEZ235 | Cisplatin-resistant urothelial cancer cells | 3-MA | [81] |
Cisplatin | Cisplatin-resistant H460 | 3-MA, trifluoperazine | [82] |
RAD001 | Apoptotic deficient H460 | 3-MA, siRNAs (Atg5, Beclin1) | [83] |
Isoliquiritigenin | Adriamycin-resistant MCF-7 | 3-MA, CQ | [84] |
p53 plasmids | Multidrug-resistant SKVCR | 3-MA | [85] |
Hernandezine | Apoptosis-resistant cell lines | Atg7-knockout, 3-MA | [86] |
HTCC-MNPs | Drug-resistant SGC7901 | 3-MA | [87] |
Quinacrine | Chemoresistant ovarian cancer cells | Baf A1 | [88] |