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Table 2 Recent studies on the pro-death role of autophagy in MDR cancer

From: Autophagy and multidrug resistance in cancer

Intervention for tumor treatment Cell line Method(s) to study autophagy References
SAHA Tamoxifen-resistant MCF-7 3-MA [77]
Tanshinones Apoptosis-resistant SW620 3-MA [78]
Edelfosine lipid nanoparticles Edelfosine-resistant leukemic K562 Starvation, staurosporine [79]
GMI protein Multidrug-resistant lung cancer cells CQ [80]
NVP-BEZ235 Cisplatin-resistant urothelial cancer cells 3-MA [81]
Cisplatin Cisplatin-resistant H460 3-MA, trifluoperazine [82]
RAD001 Apoptotic deficient H460 3-MA, siRNAs (Atg5, Beclin1) [83]
Isoliquiritigenin Adriamycin-resistant MCF-7 3-MA, CQ [84]
p53 plasmids Multidrug-resistant SKVCR 3-MA [85]
Hernandezine Apoptosis-resistant cell lines Atg7-knockout, 3-MA [86]
HTCC-MNPs Drug-resistant SGC7901 3-MA [87]
Quinacrine Chemoresistant ovarian cancer cells Baf A1 [88]
  1. SAHA, suberoylanilide hydroxamic acid; GMI, Ganoderma microsporum immunomodulatory; HTCC-MNPs, N-[(2-hydroxy-3-trimethylammonium)propyl] chitosan chloride/alginate-encapsulated Fe3O4 magnetic nanoparticle; 3-MA, 3-methyladenine; Baf A1, bafilomycin A1; siRNA, small interfering RNA; Atg, autophagy-related gene; CQ, chloroquine