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Table 3 Univariate and multivariate analyses of prognostic factors for overall survival of 1183 patients with GEP-NENs

From: Clinicopathologic characteristics and prognosis of gastroenteropancreatic neuroendocrine neoplasms: a multicenter study in South China

Variable 3-year OS rate (%) Univariate analysis Multivariate analysis
Log-rank χ2 P B SE HR 95% CI P
Gender   15.660 <0.001* 0.194 0.150 1.190 0.905–1.629 0.196
 Female 84.1        
 Male 74.9        
Age (years)   38.828 <0.001* 0.315 0.148 1.367 1.025–1.833 0.034
 ≤50 86.1        
 >50 71.4        
Tumor functionality   2.821 0.093      ND
 Nonfunctional 77.1        
 Functional 85.2        
Tumor location   82.903 <0.001*      0.460
 Stomach 64.6    NA NA 1 Reference NA
 Pancreas 75.3    0.297 0.288 1.070 0.766–2.366 0.301
 Small intestine 75.8    0.264 0.203 1.699 0.875–1.939 0.192
 Appendix 86.0    0.456 0.279 1.665 0.913–2.726 0.103
 Colon 48.5    0.216 0.213 1.227 0.817–1.883 0.311
 Rectum 90.2    0.697 0.494 2.988 0.762–5.292 0.159
Tumor size (cm)   170.024 <0.001*      0.174
 <2.0 92.6    NA NA 1 Reference NA
 2.0–4.0 71.0    0.082 0.247 1.061 0.669–1.760 0.740
 >4.0 55.7    0.364 0.263 1.411 0.859–2.408 0.167
Grade (WHO 2010 classification)   325.954 <0.001*      <0.001
 G1 93.1    NA NA 1 Reference NA
 G2 82.7    0.379 0.229 1.489 0.933–2.287 0.097
 G3 43.1    1.627 0.221 5.172 3.301–7.837 <0.001
Tumor type   336.619 <0.001*      ND
 NET 90.6        
 NEC 42.1        
 MANEC 37.9        
T category (ENETS criteria)   204.865 <0.001*      0.401
 T1 94.7    NA NA 1 Reference NA
 T2 81.6    0.190 0.307 1.189 0.663–2.206 0.536
 T3 60.1    0.454 0.308 1.594 0.862–2.878 0.140
 T4 51.3    0.456 0.344 1.563 0.804–3.097 0.185
N category (ENETS criteria)   189.400 <0.001* 0.430 0.156 1.552 1.132–2.086 0.006
 N0 88.2        
 N1 53.8        
M category (ENETS criteria)   255.266 <0.001* 0.784 0.164 2.107 1.590–3.018 <0.001
 M0 87.2        
 M1 46.8        
TNM stage (ENETS criteria)   332.157 <0.001*      ND
 I 96.0        
 II 87.3        
 III 64.0        
 IV 46.8        
Surgery   212.543 <0.001* 0.521 0.175 1.730 1.195–2.370 0.003
 Yes 84.4        
 No 39.3        
  1. OS overall survival, B beta value, SE standard error, HR hazard ratio, CI confidence interval, ND not detected, NA not applicable
  2. * Variables with P value less than 0.05 entered into multivariate analyses, except for tumor type and TNM stage