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Table 3 Prognostic values of clinical variables for predicting overall survival in 184 patients with metastatic renal cell carcinoma (including continuous variables) analyzed by using univariate and multivariate Cox regression models

From: Association of post-treatment hypoalbuminemia and survival in Chinese patients with metastatic renal cell carcinoma

Variable Univariate Multivariate
HR (95% CI) P value HR (95% CI) P value
Sex (men vs. women) 1.204 (0.806–1.799) 0.363   
Age (<65 vs. ≥65 years) 0.999 (0.983–1.016) 0.934   
Pathologic type (ccRCC vs. nccRCC) 1.408 (0.896–2.221) 0.138   
History of nephrectomy (yes vs. no) 1.103 (0.691–1.760) 0.681   
History of cytokine treatment (yes vs. no) 0.963 (0.667–1.391) 0.842   
Fuhrman grade (1–2 vs. 3–4 and unknown) 1.620 (1.260–2.081) <0.001* 1.491 (1.147–1.937) 0.003
Number of metastatic sites (1 vs. ≥ 2) 2.010 (1.384–2.918) <0.001* 1.734 (1.162–2.588) 0.007
MSKCC risk category (favorable and intermediate vs. poor) 1.927 (1.548–2.399) <0.001* 2.236 (1.747–2.862) <0.001
NLR (continuous variable) 1.163 (1.085–1.247) <0.001* 1.113 (1.034–1.199) 0.005
Drug category (sorafenib vs. sunitinib) 1.036 (0.725–1.480) 0.847   
Pre-treatment serum albumin level (continuous variable) 0.962 (0.934–0.992) 0.012* 1.008 (0.970–1.047) 0.691
Post-treatment serum albumin level (continuous variable) 0.952 (0.930–0.974) <0.001 0.967 (0.941–0.994) 0.016
  1. ccRCC, clear cell renal cell carcinoma; nccRCC, non-clear cell renal cell carcinoma; NLR, neutrophil-to-lymphocyte ratio; MSKCC, Memorial Sloan Kettering Cancer Center; HR, hazard ratio; CI, confidence interval
  2. * Variables with P values <0.05 in univariate analysis were considered for multivariate analysis