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Table 2 Prognostic values of clinical variables for predicting progression-free survival in 184 patients with metastatic renal cell carcinoma (including continuous variables) analyzed by using univariate and multivariate Cox regression models

From: Association of post-treatment hypoalbuminemia and survival in Chinese patients with metastatic renal cell carcinoma

Variable Univariate Multivariate
HR (95% CI) P value HR (95% CI) P value
Sex (men vs. women) 1.097 (0.764–1.575) 0.616   
Age (<65 vs. ≥65 years) 1.005 (0.990–1.020) 0.535   
Pathologic type (ccRCC vs. nccRCC) 1.081 (0.690–1.694) 0.733   
History of nephrectomy (yes vs. no) 1.180 (0.790–1.762) 0.418   
History of cytokine treatment (yes vs. no) 1.249 (0.896–1.742) 0.190   
Fuhrman grade (1–2 vs. 3–4 and unknown) 1.298 (1.031–1.633) 0.027* 1.211 (0.951–1.542) 0.121
Number of metastatic sites (1 vs. ≥ 2) 1.763 (1.255–2.476) 0.001* 1.576 (1.092–2.274) 0.015
MSKCC risk category (favorable and intermediate vs. poor) 1.927 (1.548–2.399) <0.001* 1.957 (1.558–2.460) 0.004
NLR (continuous variable) 1.133 (1.061–1.209) <0.001* 1.103 (1.032–1.178) 0.004
Drug category (sorafenib vs. sunitinib) 1.020 (0.739–1.408) 0.905   
Pre-treatment serum albumin level (continuous variable) 0.975 (0.949–1.003) 0.075   
Post-treatment serum albumin level (continuous variable) 0.961 (0.941–0.982) <0.001* 0.975 (0.952–0.999) 0.042
  1. ccRCC, clear cell renal cell carcinoma; nccRCC, non-clear cell renal cell carcinoma; NLR, neutrophil-to-lymphocyte ratio; MSKCC, Memorial Sloan Kettering Cancer Center; HR, hazard ratio; CI, confidence interval
  2. * Variables with P values <0.05 in univariate analysis were considered for multivariate analysis