Fig. 3

Chemoresistant PCa cells demonstrate enhanced subcutaneous tumor growth in mice. a Luminescence imaging of tumors in mice. PC3 and PC3-TxR cells were transfected with luciferase lentivial vector to construct PC3-luc and PC3-TxR-luc cells, respectively. PC3-luc and PC3-TxR-luc cells (4 × 10⁶ cells/mouse) were injected subcutaneously into the right back of male severe combined immune deficiency (SCID) mice, respectively; live images on days 14 and 28 are shown. b Tumor growth curves of PC3-luc and PC3-TxR-luc cell xenografts. Tumor volumes were recorded once a week. The mean ± SEM values of data from 10 mice per group are presented. c The photo of subcutaneous tumors excised from mice when the tumor volume was approximately 1 cm³. *P < 0.05, **P < 0.01