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Table 1 Breast cancer metastasis-regulated genes

From: Tumor microenvironment: driving forces and potential therapeutic targets for breast cancer metastasis

Target organ Function(s) in breast cancer metastasis Gene Reference(s)
Lung Promotion SPARC [1]
VCAM1 [1]
MMP2 [1]
IL-13Rα2 [1]
α6β1/4 [2]
Twist [17]
Par6 [23]
BCAR4 [37]
TNC [62]
CXCL12/CXCR4 [73]
CCL2 [74]
SERPINE2 [79]
SLPI [79]
Coco [94]
Suppression miR-126/miR-126* [35]
miR-708 [36]
Bone Promotion IL-11 [3]
   CTGF [3]
LOX [48]
CXCL12 [53, 76]
14-3- [59]
JAG1 [63]
VCAM1 [95]
Suppression miR-34a [32]
Liver Promotion αVβ5 [2]
PDK1 [30]
Brain Promotion ST6GALNAC5 [4]
miR-19a [78]
Lymph node Promotion CXCL12/CXCR4 [73]
NRP2 [81]
  1. SPARC, secreted protein acid and rich in cysteine; VCAM1, vascular cell adhesion molecule 1; MMP2, matrix metallopeptidase 2; IL-13Rα2, interleukin-13 receptor subunit alpha-2; Par6, partitioning-defective protein 6; BCAR4, breast cancer anti-estrogen resistance 4; TNC, tenascin C; CXCL12, C–X–C motif chemokine ligand 12; CXCR4, C–X–C motif chemokine receptor 4; CCL2, C–C motif chemokine ligand 2; SERPINE2, serpin family E member 2; SLPI, secretory leukocyte peptidase inhibitor; miR, microRNA; IL-11, interleukin-11; CTGF, connective tissue growth factor; LOX, lysyl oxidase; JAG1, Jagged 1; PDK1, pyruvate dehydrogenase kinase 1; ST6GALNAC5, ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; NRP2, neuropilin 2