Table 6 Frequency of grade 3–4 adverse events in the FEC and PE arms
Adverse event | FEC arm [cases (%)] | PE arm [cases (%)] | P value |
|---|---|---|---|
Hematologic | |||
Neutropenia | 9 (5.96) | 17 (11.97) | 0.031 |
Anemia | 6 (4.00) | 10 (7.04) | 0.248 |
Thrombocytopenia | 5 (3.31) | 7 (4.93) | 0.485 |
Non-hematologic | |||
Nausea | 4 (2.64) | 4 (2.82) | 0.458 |
Vomiting | 2 (1.32) | 3 (2.11) | 0.603 |
Diarrhea | 2 (1.32) | 4 (2.82) | 0.951 |
Constipation | 3 (1.99) | 4 (2.82) | 0.267 |
Hair loss | 24 (15.79) | 28 (19.72) | 0.583 |
Dermatitis | 8 (5.30) | 11 (7.75) | 0.395 |
Febrile | 1 (0.66) | 1 (0.70) | 0.965 |
Fatigue | 7 (4.64) | 10 (7.04) | 0.379 |
Hand-foot syndrome | 6 (3.97) | 5 (3.52) | 0.913 |
Allergy | 0 (0.00) | 1 (0.70) | 0.143 |