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Table 5 Studies of adjuvant chemotherapy for biliary tract cancer

From: The efficacy of fluoropyrimidine-based adjuvant chemotherapy on biliary tract cancer after R0 resection

Referencea Year Design Resection margin Tumor location Stage Arm No. of patients Overall survival
Median (months) 5-year rate (%) P value
Takada [9] 2002 Prospective R0–R2 GB II–IV FM
Observation
69
43
NA 26.0
14.4
0.0367
Murakami [11] 2009 Retrospective R0, R1 GB/BD/AoV II G + S-1
Observation
50
53
NA 57.0
24.0
<0.001
Neoptolemos [13] 2012 Prospective R0, R1 BD/AoV I–IV FL
G
Observation
31
34
31
18.3
19.5
27.2
NA NA
Kobayashi [12] 2012 Retrospective R0, R1 BD II–IV G
Observation
51
54
NA 46.0
23.0
0.002
Wirasorn [15] 2013 Retrospective R0, R1 BD 0–IV AC
Observation
138
125
21.6
13.4
40.1b
29.4b
0.01
Yamanaka [14] 2013 Retrospective R0 GB/BD/AoV I–III G
Observation
40
158
NA 68.0b
68.7b
NS
This present study   Retrospective R0 GB/BD II–III F-based
Observation
53
32
NA 52.4
35.6
0.002
  1. GB gallbladder, BD bile duct, AoV ampulla of Vater, FM 5-fluorouracil and mitomycin C, G gemcitabine, FL 5-fluorouracil and leucovorin, AC non-specific adjuvant chemotherapy, F fluoropyrimidine, NA not available, NS non-significant
  2. aThe reference is presented as the first author’s last name followed by the order number of the reference
  3. b3-year survival rate