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Table 4 The number and percentages of intrasplenic and hepatic tumor formation after intrasplenic injection of HCT116 stable cell lines (1×106 cells each) for 8 weeks

From: The loss-of-function mutations and down-regulated expression of ASB3 gene promote the growth and metastasis of colorectal cancer cells

Modified HCT116 stable cell line Number of mice Tumor formationa
Intrasplenic Liver
Vectro 8 6 (75.0) 6 (75.0)
ΔSOCS 8 6 (75.0) 6 (75.0)
WT ASB3 8 4 (50.0) 2 (25.0)*
G135E 8 7 (87.5) 8 (100)
K339I 8 7 (87.5) 8 (100)
G135E/K339I 8 8 (100) 8 (100)
  1. P < 0.05 compared with other groups (Students’ t test)
  2. a The data are presented as the number of mice with tumors followed by percentage in parentheses