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Table 2 Univariate analysis of prognostic factors of overall survival in 40 esophageal squamous cell carcinoma patients with malignant fistulae

From: Concurrent chemoradiotherapy combined with enteral nutrition support: a radical treatment strategy for esophageal squamous cell carcinoma patients with malignant fistulae

Variable HR (95% CI) P value
ECOG performance status (0–1 vs. 2) 0.76 (0.26–1.87) 0.567
Primary tumor location (upper vs. middle vs. lower) 0.44 (0.19–1.00) 0.051
T category of primary tumor 1.95 (0.68–5.56) 0.213
(T4 vs. non-T4)
Clinical stage of primary tumor (stage II vs. stage III vs. stage IV) 1.55 (0.68–3.57) 0.300
NRS score before CCRT (≥3 vs. <3) 1.13 (0.69–1.86) 0.631
NRS score after CCRT (≥3 vs. <3) 5.14 (1.72–15.31) 0.003
Increased NRS score after CCRT (yes vs. no) 0.32 (0.12–0.86) 0.024
Hemoglobin level after CCRT (>110 vs. ≤110 g/L) 1.56 (0.72–3.24) 0.724
Fistula closure (yes vs. no) 3.78 (1.36–10.61) 0.011
Fistula site (tracheobronchus vs. mediastinum) 1.55 (0.50–4.82) 0.447
Radiation dose (≥60 vs. <60 Gy) 0.46 (0.17–1.23) 0.096
Tumor response after CCRT (CR vs. non-CR) 3.53 (2.01–6.18) <0.001
  1. HR, hazard ratio; CI, confidence interval. ECOG, Eastern Cooperative Oncology Group; NRS, nutrition risk screening; CCRT, concurrent chemoradiotherapy; CR, complete response
  2. The italicized p values are statistically significant