Table 2 Univariate analysis of prognostic factors of overall survival in 40 esophageal squamous cell carcinoma patients with malignant fistulae
Variable | HR (95% CI) | P value |
|---|---|---|
ECOG performance status (0–1 vs. 2) | 0.76 (0.26–1.87) | 0.567 |
Primary tumor location (upper vs. middle vs. lower) | 0.44 (0.19–1.00) | 0.051 |
T category of primary tumor | 1.95 (0.68–5.56) | 0.213 |
(T4 vs. non-T4) | ||
Clinical stage of primary tumor (stage II vs. stage III vs. stage IV) | 1.55 (0.68–3.57) | 0.300 |
NRS score before CCRT (≥3 vs. <3) | 1.13 (0.69–1.86) | 0.631 |
NRS score after CCRT (≥3 vs. <3) | 5.14 (1.72–15.31) | 0.003 |
Increased NRS score after CCRT (yes vs. no) | 0.32 (0.12–0.86) | 0.024 |
Hemoglobin level after CCRT (>110 vs. ≤110 g/L) | 1.56 (0.72–3.24) | 0.724 |
Fistula closure (yes vs. no) | 3.78 (1.36–10.61) | 0.011 |
Fistula site (tracheobronchus vs. mediastinum) | 1.55 (0.50–4.82) | 0.447 |
Radiation dose (≥60 vs. <60 Gy) | 0.46 (0.17–1.23) | 0.096 |
Tumor response after CCRT (CR vs. non-CR) | 3.53 (2.01–6.18) | <0.001 |