Concurrent chemoradiotherapy combined with enteral nutrition support: a radical treatment strategy for esophageal squamous cell carcinoma patients with malignant fistulae

Table 1 Characteristics of 40 esophageal squamous cell carcinoma patients with malignant fistulae

Characteristic	No. of patients (%)	1-year OS rate^d (%)	P value
Sex			0.006
Men	37 (92.5)	67.6
Women	3 (7.5)	0.0
Age^a (years)	58 (41–80)
ECOG performance status			0.267
0–1	11 (27.5)	68.2
2	29 (72.5)	55.2
Primary tumor location			0.403
Upper	12 (30.0)	50.0
Middle	26 (65.0)	65.4
Lower	2 (5.0)	100.0
T category of primary tumor^b			0.392
T1	2 (5.0)	100.0
T2	3 (7.5)	100.0
T3	21 (52.5)	57.1
T4	14 (35.0)	57.1
Clinical stage of primary tumor^b			0.526
IIA–IIB	2 (5.0)	100
IIIA–IIIC	29 (72.5)	62.1
IV	9 (22.5)	55.5
NRS score of 3–4^c
Before nutrition support	22 (55.0)	–^e
After nutrition support	6 (15.0)	–
Hemoglobin level after CCRT^a (g/L)	110 (56–156)	–
Total energy intake^a (kcal/day)	2166 (1956–2213)	–
Total protein intake^a (g/kg per day)	1.53 (1.41–1.76)	–
Fistula closure	32 (80.0)	–
Time to fistula closure^a (weeks)	5 (2–11)	–
Fistula site			0.435
Trachea and bronchus	7 (17.5)	57.1
Mediastinum	33 (82.5)	63.6
Radiation dose^a (Gy)	60 (46–68)		<0.001
<60	14 (35.0)	50.0
≥60	26 (65.0)	69.2
Concurrent chemotherapy			0.333
DDP + 5-FU	7 (17.5)	42.9
Docetaxel-based regimens	33 (82.5)	66.7
Clinical tumor response after CCRT			<0.001
CR	12 (30.0)	91.7
PR	20 (50.0)	65.0
SD	3 (7.5)	33.3
PD	5 (12.5)	0

ECOG, Eastern Cooperative Oncology Group; NRS, nutrition risk screening; CCRT, concurrent chemoradiotherapy; DDP, cisplatin; 5-FU, 5-fluorouracil; CR, complete response; PR, partial response; SD, stable disease; PD, progressive disease
^aThese values are presented as median followed by range in parentheses. Other values are presented as the number of patients with the percentage in parentheses
^bBased on the American Joint Committee on Cancer tumor, node, and metastasis (TNM) classification (7th edition)
^cThe patients with NRS score of 1–2 are not listed in this table
^dOnly the values that were compared between subgroups are listed and analyzed
^eThe data were not applicable

ISSN: 2523-3548