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Table 2 Univariate Cox regression analysis of predictors for OS and DFS of ESCC patients

From: Prognostic values of apoptosis-stimulating P53-binding protein 1 and 2 and their relationships with clinical characteristics of esophageal squamous cell carcinoma patients: a retrospective study

Variable OS DFS
HR 95% CI P value HR 95% CI P value
Gender (male vs. female) 1.367 0.893–2.093 0.150 1.343 0.881–2.046 0.170
Age (≤60 vs. >60 years) 1.168 0.769–1.774 0.466 1.040 0.688–1.572 0.852
Histological differentiation (well vs. moderate vs. poor) 1.192 0.895–1.587 0.230 1.123 0.848–1.487 0.419
Tumor location (upper vs. middle vs. lower thoracic esophagus) 0.935 0.642–1.363 0.728 0.980 0.676–1.420 0.915
pTNM stage (III vs. I–II) 2.401 1.594–3.616 <0.001 2.405 1.611–3.591 <0.001
Invasive depth (T4 vs. T3 vs. T1–2) 1.672 1.145–2.442 0.008 1.663 1.143–2.418 0.008
N status (N1-3 vs. N0) 2.443 1.609–3.708 <0.001 2.383 1.586–3.581 <0.001
Tumor size (<5 vs. ≥5 cm) 1.061 0.655–1.718 0.810 1.083 0.676–1.735 0.740
ASPP1 expression (low vs. high) 0.942 0.641–1.383 0.761 0.942 0.641–1.383 0.761
ASPP2 expression (high vs. low) 0.527 0.355–0.782 0.001 0.606 0.412–0.891 0.011
P53 expression (high vs. low) 1.072 0.721–1.596 0.731 2.198 1.144–4.224 0.018
Smoking (yes vs. no) 1.023 0.686–1.527 0.910 1.020 0.689–1.509 0.921
Alcohol drinking (yes vs. no) 0.869 0.568–1.329 0.517 0.786 0.521–1.185 0.251
Radiotherapy (yes vs. no) 0.742 0.421–1.307 0.301 0.567 0.333–0.967 0.037
Chemotherapy (yes vs. no) 0.681 0.432–1.072 0.097 0.580 0.374–0.900 0.015
  1. OS overall survival, DFS disease-free survival, HR hazard ratio, CI confidence interval