Variable | OS | DFS | ||||
---|---|---|---|---|---|---|
HR | 95% CI | P value | HR | 95% CI | P value | |
Gender (male vs. female) | 1.367 | 0.893–2.093 | 0.150 | 1.343 | 0.881–2.046 | 0.170 |
Age (≤60 vs. >60 years) | 1.168 | 0.769–1.774 | 0.466 | 1.040 | 0.688–1.572 | 0.852 |
Histological differentiation (well vs. moderate vs. poor) | 1.192 | 0.895–1.587 | 0.230 | 1.123 | 0.848–1.487 | 0.419 |
Tumor location (upper vs. middle vs. lower thoracic esophagus) | 0.935 | 0.642–1.363 | 0.728 | 0.980 | 0.676–1.420 | 0.915 |
pTNM stage (III vs. I–II) | 2.401 | 1.594–3.616 | <0.001 | 2.405 | 1.611–3.591 | <0.001 |
Invasive depth (T4 vs. T3 vs. T1–2) | 1.672 | 1.145–2.442 | 0.008 | 1.663 | 1.143–2.418 | 0.008 |
N status (N1-3 vs. N0) | 2.443 | 1.609–3.708 | <0.001 | 2.383 | 1.586–3.581 | <0.001 |
Tumor size (<5 vs. ≥5 cm) | 1.061 | 0.655–1.718 | 0.810 | 1.083 | 0.676–1.735 | 0.740 |
ASPP1 expression (low vs. high) | 0.942 | 0.641–1.383 | 0.761 | 0.942 | 0.641–1.383 | 0.761 |
ASPP2 expression (high vs. low) | 0.527 | 0.355–0.782 | 0.001 | 0.606 | 0.412–0.891 | 0.011 |
P53 expression (high vs. low) | 1.072 | 0.721–1.596 | 0.731 | 2.198 | 1.144–4.224 | 0.018 |
Smoking (yes vs. no) | 1.023 | 0.686–1.527 | 0.910 | 1.020 | 0.689–1.509 | 0.921 |
Alcohol drinking (yes vs. no) | 0.869 | 0.568–1.329 | 0.517 | 0.786 | 0.521–1.185 | 0.251 |
Radiotherapy (yes vs. no) | 0.742 | 0.421–1.307 | 0.301 | 0.567 | 0.333–0.967 | 0.037 |
Chemotherapy (yes vs. no) | 0.681 | 0.432–1.072 | 0.097 | 0.580 | 0.374–0.900 | 0.015 |