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Table 2 Univariate Cox regression analysis of predictors for OS and DFS of ESCC patients

From: Prognostic values of apoptosis-stimulating P53-binding protein 1 and 2 and their relationships with clinical characteristics of esophageal squamous cell carcinoma patients: a retrospective study

Variable

OS

DFS

HR

95% CI

P value

HR

95% CI

P value

Gender (male vs. female)

1.367

0.893–2.093

0.150

1.343

0.881–2.046

0.170

Age (≤60 vs. >60 years)

1.168

0.769–1.774

0.466

1.040

0.688–1.572

0.852

Histological differentiation (well vs. moderate vs. poor)

1.192

0.895–1.587

0.230

1.123

0.848–1.487

0.419

Tumor location (upper vs. middle vs. lower thoracic esophagus)

0.935

0.642–1.363

0.728

0.980

0.676–1.420

0.915

pTNM stage (III vs. I–II)

2.401

1.594–3.616

<0.001

2.405

1.611–3.591

<0.001

Invasive depth (T4 vs. T3 vs. T1–2)

1.672

1.145–2.442

0.008

1.663

1.143–2.418

0.008

N status (N1-3 vs. N0)

2.443

1.609–3.708

<0.001

2.383

1.586–3.581

<0.001

Tumor size (<5 vs. ≥5 cm)

1.061

0.655–1.718

0.810

1.083

0.676–1.735

0.740

ASPP1 expression (low vs. high)

0.942

0.641–1.383

0.761

0.942

0.641–1.383

0.761

ASPP2 expression (high vs. low)

0.527

0.355–0.782

0.001

0.606

0.412–0.891

0.011

P53 expression (high vs. low)

1.072

0.721–1.596

0.731

2.198

1.144–4.224

0.018

Smoking (yes vs. no)

1.023

0.686–1.527

0.910

1.020

0.689–1.509

0.921

Alcohol drinking (yes vs. no)

0.869

0.568–1.329

0.517

0.786

0.521–1.185

0.251

Radiotherapy (yes vs. no)

0.742

0.421–1.307

0.301

0.567

0.333–0.967

0.037

Chemotherapy (yes vs. no)

0.681

0.432–1.072

0.097

0.580

0.374–0.900

0.015

  1. OS overall survival, DFS disease-free survival, HR hazard ratio, CI confidence interval