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Table 1 Associations between the expression of apoptosis-stimulating P53-binding protein 1 (ASPP1) and 2 (ASPP2) and P53 and clinicopathologic characteristics of the 175 esophageal squamous cell carcinoma (ESCC) patients
| Characteristic | ASPP1 expression [cases (%)] | P value | ASPP2 expression [cases (%)] | P value | P53 expression [cases (%)] | P value | |||
|---|---|---|---|---|---|---|---|---|---|
| Low | High | Low | High | Low | High | ||||
| Totala | 79 | 95 | 75 | 98 | 82 | 91 | |||
| Gender | 0.569 | 0.713 | 0.794 | ||||||
| Male | 56 (70.9) | 71 (74.7) | 54 (72.0) | 73 (74.5) | 58 (70.7) | 66 (72.5) | |||
| Female | 23 (29.1) | 24 (25.3) | 21 (28.0) | 25 (25.5) | 24 (29.3) | 25 (27.5) | |||
| Age (years) | 0.495 | 0.029 | 0.021 | ||||||
| ≤60 | 57 (72.2) | 64 (67.4) | 45 (60.0) | 74 (75.5) | 63 (76.8) | 55 (60.4) | |||
| >60 | 22 (27.8) | 31 (32.6) | 30 (40.0) | 24 (24.5) | 19 (23.2) | 36 (39.6) | |||
| Histological differentiation | 0.002 | <0.001 | 0.301 | ||||||
| Well | 14 (17.7) | 40 (42.1) | 15 (20.0) | 39 (39.8) | 21 (25.6) | 32 (35.2) | |||
| Moderate | 48 (60.8) | 41 (43.2) | 38 (50.7) | 51 (52.0) | 44 (53.7) | 46 (50.5) | |||
| Poor | 17 (21.5) | 14 (14.7) | 22 (29.3) | 8 (8.2) | 17 (20.7) | 13 (14.3) | |||
| Tumor location | 0.459 | 0.311 | 0.446 | ||||||
| Upper thoracic esophagus | 8 (10.1) | 5 (5.2) | 7 (9.3) | 7 (7.1) | 7 (8.5) | 7 (7.7) | |||
| Middle thoracic esophagus | 55 (69.6) | 68 (71.6) | 47 (62.7) | 72 (73.5) | 60 (73.2) | 60 (65.9) | |||
| Lower thoracic esophagus | 16 (20.3) | 22 (23.2) | 21 (28.0) | 19 (19.4) | 15 (18.3) | 24 (26.4) | |||
| pTNM stage | 0.628 | 0.148 | 0.400 | ||||||
| I–II | 37 (46.8) | 48 (50.5) | 33 (44.0) | 54 (55.1) | 44 (53.7) | 43 (47.3) | |||
| III | 42 (53.2) | 47 (49.5) | 42 (56.0) | 44 (44.9) | 38 (46.3) | 48 (52.7) | |||
| Invasive depth | 0.014 | 0.920 | 0.145 | ||||||
| T1–2 | 14 (17.7) | 30 (31.6) | 18 (24.0) | 26 (26.5) | 26 (31.7) | 18 (19.8) | |||
| T3 | 62 (78.5) | 55 (57.9) | 51 (68.0) | 65 (66.3) | 49 (59.8) | 67 (73.6) | |||
| T4 | 3 (3.8) | 10 (10.5) | 6 (8.0) | 7 (7.2) | 7 (8.5) | 6 (6.6) | |||
| Lymph node metastasis | 0.708 | 0.162 | 0.156 | ||||||
| Absence | 36 (45.6) | 46 (48.4) | 31 (41.3) | 51 (52.0) | 44 (53.7) | 39 (42.9) | |||
| Presence | 43 (54.4) | 49 (51.6) | 44 (58.7) | 47 (48.0) | 38 (46.3) | 52 (57.1) | |||
| Tumor size (cm) | 0.423 | 0.463 | 0.040 | ||||||
| <5 | 61 (77.2) | 78 (82.1) | 57 (76.0) | 79 (80.6) | 70 (85.4) | 66 (72.5) | |||
| ≥5 | 18 (22.8) | 17 (17.9) | 18 (24.0) | 19 (19.4) | 12 (14.6) | 25 (27.5) | |||
| Smoking | 0.924 | 0.807 | 0.171 | ||||||
| Yes | 46 (58.2) | 56 (58.9) | 43 (57.3) | 58 (59.2) | 42 (51.2) | 56 (61.5) | |||
| No | 33 (41.8) | 39 (41.1) | 32 (42.7) | 40 (40.8) | 40 (48.8) | 35 (38.5) | |||
| Alcohol drinking | 0.537 | 0.478 | 0.568 | ||||||
| Yes | 25 (31.6) | 26 (27.4) | 20 (26.7) | 31 (31.6) | 22 (26.8) | 28 (30.8) | |||
| No | 54 (68.4) | 69 (72.6) | 55 (73.3) | 67 (68.4) | 60 (73.2) | 63 (69.2) | |||
