Table 1 Associations between the expression of apoptosis-stimulating P53-binding protein 1 (ASPP1) and 2 (ASPP2) and P53 and clinicopathologic characteristics of the 175 esophageal squamous cell carcinoma (ESCC) patients
Characteristic | ASPP1 expression [cases (%)] | P value | ASPP2 expression [cases (%)] | P value | P53 expression [cases (%)] | P value | |||
|---|---|---|---|---|---|---|---|---|---|
Low | High | Â | Low | High | Low | High | |||
Totala | 79 | 95 | Â | 75 | 98 | Â | 82 | 91 | Â |
Gender | Â | Â | 0.569 | Â | Â | 0.713 | Â | Â | 0.794 |
 Male | 56 (70.9) | 71 (74.7) |  | 54 (72.0) | 73 (74.5) |  | 58 (70.7) | 66 (72.5) |  |
 Female | 23 (29.1) | 24 (25.3) |  | 21 (28.0) | 25 (25.5) |  | 24 (29.3) | 25 (27.5) |  |
Age (years) | Â | Â | 0.495 | Â | Â | 0.029 | Â | Â | 0.021 |
 ≤60 | 57 (72.2) | 64 (67.4) |  | 45 (60.0) | 74 (75.5) |  | 63 (76.8) | 55 (60.4) |  |
 >60 | 22 (27.8) | 31 (32.6) |  | 30 (40.0) | 24 (24.5) |  | 19 (23.2) | 36 (39.6) |  |
Histological differentiation | Â | Â | 0.002 | Â | Â | <0.001 | Â | Â | 0.301 |
 Well | 14 (17.7) | 40 (42.1) |  | 15 (20.0) | 39 (39.8) |  | 21 (25.6) | 32 (35.2) |  |
 Moderate | 48 (60.8) | 41 (43.2) |  | 38 (50.7) | 51 (52.0) |  | 44 (53.7) | 46 (50.5) |  |
 Poor | 17 (21.5) | 14 (14.7) |  | 22 (29.3) | 8 (8.2) |  | 17 (20.7) | 13 (14.3) |  |
Tumor location | Â | Â | 0.459 | Â | Â | 0.311 | Â | Â | 0.446 |
 Upper thoracic esophagus | 8 (10.1) | 5 (5.2) |  | 7 (9.3) | 7 (7.1) |  | 7 (8.5) | 7 (7.7) |  |
 Middle thoracic esophagus | 55 (69.6) | 68 (71.6) |  | 47 (62.7) | 72 (73.5) |  | 60 (73.2) | 60 (65.9) |  |
 Lower thoracic esophagus | 16 (20.3) | 22 (23.2) |  | 21 (28.0) | 19 (19.4) |  | 15 (18.3) | 24 (26.4) |  |
pTNM stage | Â | Â | 0.628 | Â | Â | 0.148 | Â | Â | 0.400 |
 I–II | 37 (46.8) | 48 (50.5) |  | 33 (44.0) | 54 (55.1) |  | 44 (53.7) | 43 (47.3) |  |
 III | 42 (53.2) | 47 (49.5) |  | 42 (56.0) | 44 (44.9) |  | 38 (46.3) | 48 (52.7) |  |
Invasive depth | Â | Â | 0.014 | Â | Â | 0.920 | Â | Â | 0.145 |
 T1–2 | 14 (17.7) | 30 (31.6) |  | 18 (24.0) | 26 (26.5) |  | 26 (31.7) | 18 (19.8) |  |
 T3 | 62 (78.5) | 55 (57.9) |  | 51 (68.0) | 65 (66.3) |  | 49 (59.8) | 67 (73.6) |  |
 T4 | 3 (3.8) | 10 (10.5) |  | 6 (8.0) | 7 (7.2) |  | 7 (8.5) | 6 (6.6) |  |
Lymph node metastasis | Â | Â | 0.708 | Â | Â | 0.162 | Â | Â | 0.156 |
 Absence | 36 (45.6) | 46 (48.4) |  | 31 (41.3) | 51 (52.0) |  | 44 (53.7) | 39 (42.9) |  |
 Presence | 43 (54.4) | 49 (51.6) |  | 44 (58.7) | 47 (48.0) |  | 38 (46.3) | 52 (57.1) |  |
Tumor size (cm) | Â | Â | 0.423 | Â | Â | 0.463 | Â | Â | 0.040 |
 <5 | 61 (77.2) | 78 (82.1) |  | 57 (76.0) | 79 (80.6) |  | 70 (85.4) | 66 (72.5) |  |
 ≥5 | 18 (22.8) | 17 (17.9) |  | 18 (24.0) | 19 (19.4) |  | 12 (14.6) | 25 (27.5) |  |
Smoking | Â | Â | 0.924 | Â | Â | 0.807 | Â | Â | 0.171 |
 Yes | 46 (58.2) | 56 (58.9) |  | 43 (57.3) | 58 (59.2) |  | 42 (51.2) | 56 (61.5) |  |
 No | 33 (41.8) | 39 (41.1) |  | 32 (42.7) | 40 (40.8) |  | 40 (48.8) | 35 (38.5) |  |
Alcohol drinking | Â | Â | 0.537 | Â | Â | 0.478 | Â | Â | 0.568 |
 Yes | 25 (31.6) | 26 (27.4) |  | 20 (26.7) | 31 (31.6) |  | 22 (26.8) | 28 (30.8) |  |
 No | 54 (68.4) | 69 (72.6) |  | 55 (73.3) | 67 (68.4) |  | 60 (73.2) | 63 (69.2) |  |