|
Characteristic
|
ASPP1 expression [cases (%)]
|
P value
|
ASPP2 expression [cases (%)]
|
P value
|
P53 expression [cases (%)]
|
P value
|
|---|
|
Low
|
High
| |
Low
|
High
|
Low
|
High
|
|---|
|
Totala
|
79
|
95
| |
75
|
98
| |
82
|
91
| |
|
Gender
| | |
0.569
| | |
0.713
| | |
0.794
|
|
Male
|
56 (70.9)
|
71 (74.7)
| |
54 (72.0)
|
73 (74.5)
| |
58 (70.7)
|
66 (72.5)
| |
|
Female
|
23 (29.1)
|
24 (25.3)
| |
21 (28.0)
|
25 (25.5)
| |
24 (29.3)
|
25 (27.5)
| |
|
Age (years)
| | |
0.495
| | |
0.029
| | |
0.021
|
|
≤60
|
57 (72.2)
|
64 (67.4)
| |
45 (60.0)
|
74 (75.5)
| |
63 (76.8)
|
55 (60.4)
| |
|
>60
|
22 (27.8)
|
31 (32.6)
| |
30 (40.0)
|
24 (24.5)
| |
19 (23.2)
|
36 (39.6)
| |
|
Histological differentiation
| | |
0.002
| | |
<0.001
| | |
0.301
|
|
Well
|
14 (17.7)
|
40 (42.1)
| |
15 (20.0)
|
39 (39.8)
| |
21 (25.6)
|
32 (35.2)
| |
|
Moderate
|
48 (60.8)
|
41 (43.2)
| |
38 (50.7)
|
51 (52.0)
| |
44 (53.7)
|
46 (50.5)
| |
|
Poor
|
17 (21.5)
|
14 (14.7)
| |
22 (29.3)
|
8 (8.2)
| |
17 (20.7)
|
13 (14.3)
| |
|
Tumor location
| | |
0.459
| | |
0.311
| | |
0.446
|
|
Upper thoracic esophagus
|
8 (10.1)
|
5 (5.2)
| |
7 (9.3)
|
7 (7.1)
| |
7 (8.5)
|
7 (7.7)
| |
|
Middle thoracic esophagus
|
55 (69.6)
|
68 (71.6)
| |
47 (62.7)
|
72 (73.5)
| |
60 (73.2)
|
60 (65.9)
| |
|
Lower thoracic esophagus
|
16 (20.3)
|
22 (23.2)
| |
21 (28.0)
|
19 (19.4)
| |
15 (18.3)
|
24 (26.4)
| |
|
pTNM stage
| | |
0.628
| | |
0.148
| | |
0.400
|
|
I–II
|
37 (46.8)
|
48 (50.5)
| |
33 (44.0)
|
54 (55.1)
| |
44 (53.7)
|
43 (47.3)
| |
|
III
|
42 (53.2)
|
47 (49.5)
| |
42 (56.0)
|
44 (44.9)
| |
38 (46.3)
|
48 (52.7)
| |
|
Invasive depth
| | |
0.014
| | |
0.920
| | |
0.145
|
|
T1–2
|
14 (17.7)
|
30 (31.6)
| |
18 (24.0)
|
26 (26.5)
| |
26 (31.7)
|
18 (19.8)
| |
|
T3
|
62 (78.5)
|
55 (57.9)
| |
51 (68.0)
|
65 (66.3)
| |
49 (59.8)
|
67 (73.6)
| |
|
T4
|
3 (3.8)
|
10 (10.5)
| |
6 (8.0)
|
7 (7.2)
| |
7 (8.5)
|
6 (6.6)
| |
|
Lymph node metastasis
| | |
0.708
| | |
0.162
| | |
0.156
|
|
Absence
|
36 (45.6)
|
46 (48.4)
| |
31 (41.3)
|
51 (52.0)
| |
44 (53.7)
|
39 (42.9)
| |
|
Presence
|
43 (54.4)
|
49 (51.6)
| |
44 (58.7)
|
47 (48.0)
| |
38 (46.3)
|
52 (57.1)
| |
|
Tumor size (cm)
| | |
0.423
| | |
0.463
| | |
0.040
|
|
<5
|
61 (77.2)
|
78 (82.1)
| |
57 (76.0)
|
79 (80.6)
| |
70 (85.4)
|
66 (72.5)
| |
|
≥5
|
18 (22.8)
|
17 (17.9)
| |
18 (24.0)
|
19 (19.4)
| |
12 (14.6)
|
25 (27.5)
| |
|
Smoking
| | |
0.924
| | |
0.807
| | |
0.171
|
|
Yes
|
46 (58.2)
|
56 (58.9)
| |
43 (57.3)
|
58 (59.2)
| |
42 (51.2)
|
56 (61.5)
| |
|
No
|
33 (41.8)
|
39 (41.1)
| |
32 (42.7)
|
40 (40.8)
| |
40 (48.8)
|
35 (38.5)
| |
|
Alcohol drinking
| | |
0.537
| | |
0.478
| | |
0.568
|
|
Yes
|
25 (31.6)
|
26 (27.4)
| |
20 (26.7)
|
31 (31.6)
| |
22 (26.8)
|
28 (30.8)
| |
|
No
|
54 (68.4)
|
69 (72.6)
| |
55 (73.3)
|
67 (68.4)
| |
60 (73.2)
|
63 (69.2)
| |
-
aThe cases with insufficient tissue for immunohistochemical staining were excluded from relevant analysis
