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Table 1 Associations between the expression of apoptosis-stimulating P53-binding protein 1 (ASPP1) and 2 (ASPP2) and P53 and clinicopathologic characteristics of the 175 esophageal squamous cell carcinoma (ESCC) patients

From: Prognostic values of apoptosis-stimulating P53-binding protein 1 and 2 and their relationships with clinical characteristics of esophageal squamous cell carcinoma patients: a retrospective study

Characteristic ASPP1 expression [cases (%)] P value ASPP2 expression [cases (%)] P value P53 expression [cases (%)] P value
Low High   Low High Low High
Totala 79 95   75 98   82 91  
Gender    0.569    0.713    0.794
 Male 56 (70.9) 71 (74.7)   54 (72.0) 73 (74.5)   58 (70.7) 66 (72.5)  
 Female 23 (29.1) 24 (25.3)   21 (28.0) 25 (25.5)   24 (29.3) 25 (27.5)  
Age (years)    0.495    0.029    0.021
 ≤60  57 (72.2) 64 (67.4)   45 (60.0) 74 (75.5)   63 (76.8) 55 (60.4)  
 >60 22 (27.8) 31 (32.6)   30 (40.0) 24 (24.5)   19 (23.2) 36 (39.6)  
Histological differentiation    0.002    <0.001    0.301
 Well 14 (17.7) 40 (42.1)   15 (20.0) 39 (39.8)   21 (25.6) 32 (35.2)  
 Moderate 48 (60.8) 41 (43.2)   38 (50.7) 51 (52.0)   44 (53.7) 46 (50.5)  
 Poor 17 (21.5) 14 (14.7)   22 (29.3) 8 (8.2)   17 (20.7) 13 (14.3)  
Tumor location    0.459    0.311    0.446
 Upper thoracic esophagus 8 (10.1) 5 (5.2)   7 (9.3) 7 (7.1)   7 (8.5) 7 (7.7)  
 Middle thoracic esophagus 55 (69.6) 68 (71.6)   47 (62.7) 72 (73.5)   60 (73.2) 60 (65.9)  
 Lower thoracic esophagus 16 (20.3) 22 (23.2)   21 (28.0) 19 (19.4)   15 (18.3) 24 (26.4)  
pTNM stage    0.628    0.148    0.400
 I–II 37 (46.8) 48 (50.5)   33 (44.0) 54 (55.1)   44 (53.7) 43 (47.3)  
 III 42 (53.2) 47 (49.5)   42 (56.0) 44 (44.9)   38 (46.3) 48 (52.7)  
Invasive depth    0.014    0.920    0.145
 T1–2 14 (17.7) 30 (31.6)   18 (24.0) 26 (26.5)   26 (31.7) 18 (19.8)  
 T3 62 (78.5) 55 (57.9)   51 (68.0) 65 (66.3)   49 (59.8) 67 (73.6)  
 T4 3 (3.8) 10 (10.5)   6 (8.0) 7 (7.2)   7 (8.5) 6 (6.6)  
Lymph node metastasis    0.708    0.162    0.156
 Absence 36 (45.6) 46 (48.4)   31 (41.3) 51 (52.0)   44 (53.7) 39 (42.9)  
 Presence 43 (54.4) 49 (51.6)   44 (58.7) 47 (48.0)   38 (46.3) 52 (57.1)  
Tumor size (cm)    0.423    0.463    0.040
 <5 61 (77.2) 78 (82.1)   57 (76.0) 79 (80.6)   70 (85.4) 66 (72.5)  
 ≥5 18 (22.8) 17 (17.9)   18 (24.0) 19 (19.4)   12 (14.6) 25 (27.5)  
Smoking    0.924    0.807    0.171
 Yes 46 (58.2) 56 (58.9)   43 (57.3) 58 (59.2)   42 (51.2) 56 (61.5)  
 No 33 (41.8) 39 (41.1)   32 (42.7) 40 (40.8)   40 (48.8) 35 (38.5)  
Alcohol drinking    0.537    0.478    0.568
 Yes 25 (31.6) 26 (27.4)   20 (26.7) 31 (31.6)   22 (26.8) 28 (30.8)  
 No 54 (68.4) 69 (72.6)   55 (73.3) 67 (68.4)   60 (73.2) 63 (69.2)  
  1. aThe cases with insufficient tissue for immunohistochemical staining were excluded from relevant analysis