Fig. 1

Immunohistochemical staining of apoptosis-stimulating P53-binding protein 1 (ASPP1) and 2 (ASPP2) and P53 in esophageal squamous cell carcinoma (ESCC) and noncancerous tissues. ASPP1 is primarily expressed in the cytoplasm and is strongly positive in noncancerous tissues and ESCCs. ASPP2 is primarily expressed in the perinuclear region and is moderately positive in noncancerous tissues while strongly positive in ESCC. P53 is primarily expressed in the nucleus in most ESCCs, but is seldom detected in noncancerous tissues