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Table 4 Multivariate prognostic analyses of anatomic factors in the 749 patients with NPC

From: Prognostic factors and failure patterns in non-metastatic nasopharyngeal carcinoma after intensity-modulated radiotherapy

Variable

Disease failure

Local failure

Distant failure

HR (95% CI)

P value

HR (95% CI)

P value

HR (95% CI)

P value

Age (>50 vs. ≤50 years)

1.857 (1.365–2.516)

<0.001

0.996 (0.476–2.080)

0.997

1.433 (0.967–2.120)

0.074

Histological type (WHO II/III vs. WHO I)

1.371 (0.829–2.264)

0.221

0.843 (0.327–2.125)

0.710

3.614 (1.804–7.219)

<0.001

Chemotherapy (CCRT, induction with CCRT, and CCRT with adjuvant vs. none)

1.207 (0.794–1.843)

0.383

0.624 (0.273–1.410)

0.269

1.459 (0.834–2.569)

0.190

Nasal cavity involvement (yes vs. no)

0.946 (0.683–1.311)

0.741

0.867 (0.429–1.752)

0.690

0.818 (0.547–1.225)

0.330

Oropharyngeal involvement (yes vs. no)

1.208 (0.812–1.798)

 

0.431 (0.130–1.432)

0.169

1.491 (0.941–2.362)

0.089

Parapharyngeal involvement (yes vs. no)

1.843 (1.144–2.969)

0.011

2.212 (0.690–7.141)

0.172

2.040 (1.115–3.764)

0.017

Skull base involvement (yes vs. no)

1.273 (0.851–1.906)

0.240

2.113 (0.790–5.651)

0.136

1.248 (0.759–2.052)

0.383

Paranasal sinus involvement (yes vs. no)

1.078 (0.704–1.650)

0.729

1.246 (0.526–2.949)

0.617

0.937 (0.543–1.616)

0.815

Cranial nerve involvement (yes vs. no)

1.394 (0.867–2.178)

0.139

2.012 (0.833–4.881)

0.120

1.247 (0.703–2.218)

0.399

Intracranial involvement (yes vs. no)

1.303 (0.871–1.950)

0.198

1.119 (0.468–2.674)

0.800

1.538 (1.056–2.490)

0.040

Infratemporal fossa involvement (yes vs. no)

1.035 (0.564–1.875)

0.893

0.616 (0.175–2.137)

0.458

0.737 (0.320–1.675)

0.467

Orbit involvement (yes vs. no)

1.641 (0.914–2.937)

0.109

4.067 (1.369–12.103)

0.011

1.537 (0.733–3.231)

0.251

Retropharyngeal lymph node involvement (yes vs. no)

1.583 (1.102–2.273)

0.011

1.519 (0.679–3.406)

0.309

1.565 (1.078–2.499)

0.030

Cervical lymph node involvement

 Longest diameter (>6 cm vs. ≤6 cm)

2.829 (1.603–4.991)

<0.001

0.815 (0.107–6.219)

0.840

3.050 (1.625–5.727)

0.001

 Laterality (bilateral vs. unilateral)

1.475 (1.031–2.107)

0.032

0.398 (0.672–6.513)

0.423

1.625 (1.078–2.453)

0.019

 Ho’s location (Ho’s vs. above Ho’s)

2.396 (1.435–3.996)

0.001

0.567 (0.073–4.272)

0.583

2.859 (1.617–5.061)

<0.001

  1. HR hazard ratio, CI confidence interval, CCRT current chemoradiotherapy