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Table 4 Multivariate prognostic analyses of anatomic factors in the 749 patients with NPC

From: Prognostic factors and failure patterns in non-metastatic nasopharyngeal carcinoma after intensity-modulated radiotherapy

Variable Disease failure Local failure Distant failure
HR (95% CI) P value HR (95% CI) P value HR (95% CI) P value
Age (>50 vs. ≤50 years) 1.857 (1.365–2.516) <0.001 0.996 (0.476–2.080) 0.997 1.433 (0.967–2.120) 0.074
Histological type (WHO II/III vs. WHO I) 1.371 (0.829–2.264) 0.221 0.843 (0.327–2.125) 0.710 3.614 (1.804–7.219) <0.001
Chemotherapy (CCRT, induction with CCRT, and CCRT with adjuvant vs. none) 1.207 (0.794–1.843) 0.383 0.624 (0.273–1.410) 0.269 1.459 (0.834–2.569) 0.190
Nasal cavity involvement (yes vs. no) 0.946 (0.683–1.311) 0.741 0.867 (0.429–1.752) 0.690 0.818 (0.547–1.225) 0.330
Oropharyngeal involvement (yes vs. no) 1.208 (0.812–1.798)   0.431 (0.130–1.432) 0.169 1.491 (0.941–2.362) 0.089
Parapharyngeal involvement (yes vs. no) 1.843 (1.144–2.969) 0.011 2.212 (0.690–7.141) 0.172 2.040 (1.115–3.764) 0.017
Skull base involvement (yes vs. no) 1.273 (0.851–1.906) 0.240 2.113 (0.790–5.651) 0.136 1.248 (0.759–2.052) 0.383
Paranasal sinus involvement (yes vs. no) 1.078 (0.704–1.650) 0.729 1.246 (0.526–2.949) 0.617 0.937 (0.543–1.616) 0.815
Cranial nerve involvement (yes vs. no) 1.394 (0.867–2.178) 0.139 2.012 (0.833–4.881) 0.120 1.247 (0.703–2.218) 0.399
Intracranial involvement (yes vs. no) 1.303 (0.871–1.950) 0.198 1.119 (0.468–2.674) 0.800 1.538 (1.056–2.490) 0.040
Infratemporal fossa involvement (yes vs. no) 1.035 (0.564–1.875) 0.893 0.616 (0.175–2.137) 0.458 0.737 (0.320–1.675) 0.467
Orbit involvement (yes vs. no) 1.641 (0.914–2.937) 0.109 4.067 (1.369–12.103) 0.011 1.537 (0.733–3.231) 0.251
Retropharyngeal lymph node involvement (yes vs. no) 1.583 (1.102–2.273) 0.011 1.519 (0.679–3.406) 0.309 1.565 (1.078–2.499) 0.030
Cervical lymph node involvement
 Longest diameter (>6 cm vs. ≤6 cm) 2.829 (1.603–4.991) <0.001 0.815 (0.107–6.219) 0.840 3.050 (1.625–5.727) 0.001
 Laterality (bilateral vs. unilateral) 1.475 (1.031–2.107) 0.032 0.398 (0.672–6.513) 0.423 1.625 (1.078–2.453) 0.019
 Ho’s location (Ho’s vs. above Ho’s) 2.396 (1.435–3.996) 0.001 0.567 (0.073–4.272) 0.583 2.859 (1.617–5.061) <0.001
  1. HR hazard ratio, CI confidence interval, CCRT current chemoradiotherapy