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Table 1 Treatment schedule (CIRT plus concurrent chemotherapy) for dose escalation in patients with locally recurrent nasopharyngeal carcinoma (NPC)

From: Phase I/II trial evaluating concurrent carbon-ion radiotherapy plus chemotherapy for salvage treatment of locally recurrent nasopharyngeal carcinoma

 Dose level Dose and fractionation Total dose (GyE) pDLT (%) BED2 (GyE) BED9 (GyE)
1 2.5 GyE × 21 fractions 52.5 <5 118.1 67.1
2 2.5 GyE × 22 fractions (starting dose) 55 10 123.8 70.3
3 2.5 GyE × 23 fractions 57.5 20 129.4 73.5
4 2.5 GyE × 24 fractions 60 30 135.0 76.7
5 2.5 GyE × 25 fractions 62.5 40 140.6 79.9
6 2.5 GyE × 26 fractions 65 50 146.3 83.1
  1. The starting dose of the trial is at 2.5 GyE × 22 (in italics)
  2. CIRT carbon-ion radiotherapy, GyE gray equivalent, pDLT probability of dose-limiting toxicities, BED biological effective dose, BED2 cumulative BED with an α/β ratio of 2, BED9 cumulative BED with an α/β ratio of 9
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