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Table 1 Treatment schedule (CIRT plus concurrent chemotherapy) for dose escalation in patients with locally recurrent nasopharyngeal carcinoma (NPC)

From: Phase I/II trial evaluating concurrent carbon-ion radiotherapy plus chemotherapy for salvage treatment of locally recurrent nasopharyngeal carcinoma

 Dose level

Dose and fractionation

Total dose (GyE)

pDLT (%)

BED2 (GyE)

BED9 (GyE)

1

2.5 GyE × 21 fractions

52.5

<5

118.1

67.1

2

2.5 GyE × 22 fractions (starting dose)

55

10

123.8

70.3

3

2.5 GyE × 23 fractions

57.5

20

129.4

73.5

4

2.5 GyE × 24 fractions

60

30

135.0

76.7

5

2.5 GyE × 25 fractions

62.5

40

140.6

79.9

6

2.5 GyE × 26 fractions

65

50

146.3

83.1

  1. The starting dose of the trial is at 2.5 GyE × 22 (in italics)
  2. CIRT carbon-ion radiotherapy, GyE gray equivalent, pDLT probability of dose-limiting toxicities, BED biological effective dose, BED2 cumulative BED with an α/β ratio of 2, BED9 cumulative BED with an α/β ratio of 9
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Cancer Communications

ISSN: 2523-3548

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