Dose level
|
Dose and fractionation
|
Total dose (GyE)
|
pDLT (%)
|
BED2 (GyE)
|
BED9 (GyE)
|
---|
1
|
2.5 GyE × 21 fractions
|
52.5
|
<5
|
118.1
|
67.1
|
2
|
2.5 GyE × 22 fractions (starting dose)
|
55
|
10
|
123.8
|
70.3
|
3
|
2.5 GyE × 23 fractions
|
57.5
|
20
|
129.4
|
73.5
|
4
|
2.5 GyE × 24 fractions
|
60
|
30
|
135.0
|
76.7
|
5
|
2.5 GyE × 25 fractions
|
62.5
|
40
|
140.6
|
79.9
|
6
|
2.5 GyE × 26 fractions
|
65
|
50
|
146.3
|
83.1
|
- The starting dose of the trial is at 2.5 GyE × 22 (in italics)
-
CIRT carbon-ion radiotherapy, GyE gray equivalent, pDLT probability of dose-limiting toxicities, BED biological effective dose, BED2 cumulative BED with an α/β ratio of 2, BED9 cumulative BED with an α/β ratio of 9