The clinical association of programmed cell death protein 4 (PDCD4) with solid tumors and its prognostic significance: a meta-analysis

Table 2 Associations between PDCD4 down-regulation and the clinicopathologic parameters of patients with solid tumors

Parameter	Study subjects	Reference(s)	Total cases	PDCD4 expression (cases)^a		OR	95% CI	I ² (%)	P
Parameter	Study subjects	Reference(s)	Total cases	Negative	Positive	OR	95% CI	I ² (%)	P
Tumor size (large vs. small)	Tumor type
	Digestive system cancer	[7, 14–16]	530	114 vs. 169	84 vs. 163	1.49	1.00–2.22	51.3	0.08
	Urinary system cancer	[17]	66	6 vs. 29	5 vs. 26	1.08	0.29–3.95	NA	NA
	Total		596	120 vs. 198	89 vs. 189	1.45	0.99-2.12	40.8	0.13
T category (T3 + 4 vs. T1 + 2)	Tumor type
	Digestive system cancer	[15, 19]	238	96 vs. 24	95 vs. 23	0.98	0.46-2.08	25.1	0.26
	Urinary system cancer	[17]	66	22 vs. 13	8 vs. 23	4.87	1.69–14.0	NA	NA
	Head and neck cancer	[18]	190	44 vs. 73	16 vs. 57	2.15	1.10–4.19	NA	NA
	Total		494	162 vs. 110	119 vs. 103	1.68	0.82–3.43	60.8	0.04
N category (N⁺ vs. N⁻)	Tumor type
	Digestive system cancer	[15, 19, 23]	465	164 vs. 119	91 vs. 91	1.02	0.53-1.93	58.5	0.05
	Head and neck cancer	[20, 21]	114	19 vs. 36	11 vs. 48	3.39	0.59-19.53	55.3	0.14
	Respiratory system cancer	[22]	124	44 vs. 59	11 vs. 10	0.68	0.26–1.74	NA	NA
	Population
	Asian	[15, 19–21, 23]	579	183 vs. 155	102 vs. 139	1.26	0.68–2.33	58.8	0.02
	European	[22]	124	44 vs. 59	11 vs. 10	0.68	0.26–1.74	NA	NA
	Total		703	227 vs. 214	113 vs. 149	1.15	0.67–1.68	55.4	0.03
M category (M⁺ vs. M⁻)	Tumor type
	Urinary system tumor	[17]	66	22 vs. 13	8 vs. 23	4.87	1.69–14.0	NA	NA
	Head and neck cancer	[18]	190	10 vs. 107	4 vs. 69	1.61	0.49–5.34	NA	NA
	Digestive system cancer	[19, 23]	213	4 vs. 117	4 vs. 88	0.72	0.09–5.83	54	0.14
	Total		469	36 vs. 237	16 vs. 180	2.51	1.20–5.26	46.2	0.10

OR odds ratio, CI confidence interval, NA not available
^aThe data of PDCD4 expression are expressed as the number of cases in the former subgroup versus the number of cases in the latter subgroup, e.g., the number of cases in the large tumor subgroup versus the number of cases in the small tumor subgroup

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