|
Parameter
|
Study subjects
|
Reference(s)
|
Total cases
|
PDCD4 expression (cases)a
|
OR
|
95% CI
|
I
2 (%)
|
P
|
|---|
|
Negative
|
Positive
|
|---|
|
Tumor size (large vs. small)
|
Tumor type
|
|
Digestive system cancer
|
[7, 14–16]
|
530
|
114 vs. 169
|
84 vs. 163
|
1.49
|
1.00–2.22
|
51.3
|
0.08
|
|
Urinary system cancer
|
[17]
|
66
|
6 vs. 29
|
5 vs. 26
|
1.08
|
0.29–3.95
|
NA
|
NA
|
|
Total
| |
596
|
120 vs. 198
|
89 vs. 189
|
1.45
|
0.99-2.12
|
40.8
|
0.13
|
|
T category (T3 + 4 vs. T1 + 2)
|
Tumor type
|
|
Digestive system cancer
|
[15, 19]
|
238
|
96 vs. 24
|
95 vs. 23
|
0.98
|
0.46-2.08
|
25.1
|
0.26
|
|
Urinary system cancer
|
[17]
|
66
|
22 vs. 13
|
8 vs. 23
|
4.87
|
1.69–14.0
|
NA
|
NA
|
|
Head and neck cancer
|
[18]
|
190
|
44 vs. 73
|
16 vs. 57
|
2.15
|
1.10–4.19
|
NA
|
NA
|
|
Total
| |
494
|
162 vs. 110
|
119 vs. 103
|
1.68
|
0.82–3.43
|
60.8
|
0.04
|
|
N category (N+ vs. N−)
|
Tumor type
|
|
Digestive system cancer
|
[15, 19, 23]
|
465
|
164 vs. 119
|
91 vs. 91
|
1.02
|
0.53-1.93
|
58.5
|
0.05
|
|
Head and neck cancer
|
[20, 21]
|
114
|
19 vs. 36
|
11 vs. 48
|
3.39
|
0.59-19.53
|
55.3
|
0.14
|
|
Respiratory system cancer
|
[22]
|
124
|
44 vs. 59
|
11 vs. 10
|
0.68
|
0.26–1.74
|
NA
|
NA
|
|
Population
|
|
Asian
|
[15, 19–21, 23]
|
579
|
183 vs. 155
|
102 vs. 139
|
1.26
|
0.68–2.33
|
58.8
|
0.02
|
|
European
|
[22]
|
124
|
44 vs. 59
|
11 vs. 10
|
0.68
|
0.26–1.74
|
NA
|
NA
|
|
Total
| |
703
|
227 vs. 214
|
113 vs. 149
|
1.15
|
0.67–1.68
|
55.4
|
0.03
|
|
M category (M+ vs. M−)
|
Tumor type
|
|
Urinary system tumor
|
[17]
|
66
|
22 vs. 13
|
8 vs. 23
|
4.87
|
1.69–14.0
|
NA
|
NA
|
|
Head and neck cancer
|
[18]
|
190
|
10 vs. 107
|
4 vs. 69
|
1.61
|
0.49–5.34
|
NA
|
NA
|
|
Digestive system cancer
|
[19, 23]
|
213
|
4 vs. 117
|
4 vs. 88
|
0.72
|
0.09–5.83
|
54
|
0.14
|
|
Total
| |
469
|
36 vs. 237
|
16 vs. 180
|
2.51
|
1.20–5.26
|
46.2
|
0.10
|
-
OR odds ratio, CI confidence interval, NA not available
-
aThe data of PDCD4 expression are expressed as the number of cases in the former subgroup versus the number of cases in the latter subgroup, e.g., the number of cases in the large tumor subgroup versus the number of cases in the small tumor subgroup
