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Table 5 Univariate analysis of factors related to survival of patients with CHC

From: Combined hepatocellular and cholangiocarcinoma originating from the same clone: a pathomolecular evidence-based study

Variable No. of cases Median overall survival (months) P*
Age (years)    0.080
 <50 16 12  
 ≥50 18 27  
Sex    0.623
 Men 30 14  
 Women 4 22  
Tumor size (cm)    0.012
 <3 9 29  
 ≥3 25 10  
HBsAg    0.660
 Positive 32 14  
 Negative 2 6  
Microvascular invasion of HCC   1 0.019
 Yes 17 0  
 No 17 29  
Lymph node metastasis of ICC    <0.001
 Yes 6 7  
 No 28 22  
Cirrhosis    0.004
 Yes 20 10  
 No 14 29  
Serum AFP level (ng/mL)
 <20 vs. ≥20 10 vs. 24 18 vs. 12 0.907
 <1000 vs. ≥1000 22 vs. 12 18 vs. 10 0.311
Serum CA19–9 level (ng/mL)
 <38 vs. ≥38 20 vs. 14 22 vs. 10 0.174
 <100 vs. ≥100 30 vs. 4 22 vs. 14 0.958
Edmondson grade of HCC    0.847
 I–II 4 8  
 III–IV 30 18  
Histologic differentiation of ICC    <0.001
 Well to moderate 24 27  
 Poor 10 7  
  1. HBsAg hepatitis B surface antigen, AFP ɑ-fetoprotein, CA19-9 carbohydrate antigen 19-9, HCC hepatocellular carcinoma, ICC intrahepatic cholangiocarcinoma
  2. *Log-rank test