Combined hepatocellular and cholangiocarcinoma originating from the same clone: a pathomolecular evidence-based study

Table 5 Univariate analysis of factors related to survival of patients with CHC

Variable	No. of cases	Median overall survival (months)	P*
Age (years)			0.080
<50	16	12
≥50	18	27
Sex			0.623
Men	30	14
Women	4	22
Tumor size (cm)			0.012
<3	9	29
≥3	25	10
HBsAg			0.660
Positive	32	14
Negative	2	6
Microvascular invasion of HCC		1	0.019
Yes	17	0
No	17	29
Lymph node metastasis of ICC			<0.001
Yes	6	7
No	28	22
Cirrhosis			0.004
Yes	20	10
No	14	29
Serum AFP level (ng/mL)
<20 vs. ≥20	10 vs. 24	18 vs. 12	0.907
<1000 vs. ≥1000	22 vs. 12	18 vs. 10	0.311
Serum CA19–9 level (ng/mL)
<38 vs. ≥38	20 vs. 14	22 vs. 10	0.174
<100 vs. ≥100	30 vs. 4	22 vs. 14	0.958
Edmondson grade of HCC			0.847
I–II	4	8
III–IV	30	18
Histologic differentiation of ICC			<0.001
Well to moderate	24	27
Poor	10	7

HBsAg hepatitis B surface antigen, AFP ɑ-fetoprotein, CA19-9 carbohydrate antigen 19-9, HCC hepatocellular carcinoma, ICC intrahepatic cholangiocarcinoma
^*Log-rank test