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Table 2 Comparison of clinicopathologic features among patients with CHC, SHC, pure HCC, and pure ICC

From: Combined hepatocellular and cholangiocarcinoma originating from the same clone: a pathomolecular evidence-based study

Characteristic

CHC (n = 34)

SHC (n = 29)

Pure HCC (n = 50)

Pure ICC (n = 50)

P valuec

 

V1

V2

V3

Sex

 Men

30 (88.2)

25 (86.2)

47 (94.0)

35 (70.0)

0.810

0.383

0.051

 Women

4 (11.8)

4 (13.8)

3 (6.0)

15 (30.0)

Age (years)a

52 (24–78)

49 (24–81)

53 (26–73)

60 (42–81)

0.434

0.713

0.342

Tumor size (cm)b

4.05 ± 2.45

3.49 ± 2.11▲

6.26 ± 2.81

5.24 ± 3.42

0.237▲

0.146

 
 

2.96 ± 1.68▼

  

0.168▼

 

0.293

HBsAg (+)

32 (94.1)

27 (93.1)

43 (86.0)

28 (56.0)

1.000

0.301

<0.001

Liver cirrhosis

20 (58.9)

12 (41.4)

34 (86.0)

12 (24.0)

0.167

0.389

<0.001

Vascular invasion

17 (50.0)

9 (31.0)

1 (2.0)

6 (12.0)

0.128

<0.001

<0.001

Lymph node metastasis

6 (17.6)

4 (13.8)

0 (0.0)

10 (20.0)

0.741

0.003

0.787

AFP ≥20 μg/L

24 (70.6)

20 (69.0)

33 (66.0)

15 (30.0)

0.889

0.659

<0.001

CA19–9 ≥38 U/mL

14 (41.2)

27 (93.1)

2 (2.0)

22 (44.0)

<0.001

<0.001

0.797

AFP ≥20 μg/L and CA19–9 ≥38 U/mL

10 (29.4)

4 (13.8)

1 (2.0)

5 (10.0)

0.137

<0.001

0.023

HCC

 Histologic type

  Coarse trabecular pattern

21 (61.8)

19 (65.5)

34 (68.0)

 

0.025

0.834

 

  Fine trabecular pattern

3 (8.8)

8 (27.6)

4 (8.0)

    

  Others

10 (29.4)

2 (6.9)

12 (24.0)

    

 Edmondson grade

  I–II

4 (11.8)

11 (37.9)

9 (18.0)

 

0.015

0.438

 

  III–IV

30 (88.2)

18 (62.1)

41 (82.0)

    

ICC

 Histologic type

  Tubular pattern

29 (85.3)

28 (96.6)

 

46 (92.0)

0.139

 

0.266

  Others

5 (14.7)

1 (3.4)

 

4 (8.0)

   

 Differentiation grade

  Moderate and well

24 (70.6)

25 (86.2)

 

29 (58.0)

0.137

 

0.241

  Poor

10 (29.4)

4 (13.8)

 

21 (42.0)

   

Overall survival time (months)b

15.37 ± 2.04

24 ± 4.23

29.2 ± 4.1

10.1 ± 2.3

0.047

0.021

0.017

Disease-free survival time (months)b

8.85 ± 1.3

16.9 ± 3.6

22.7 ± 3.9

5.62 ± 0.7

0.038

<0.001

0.397

  1. CHC combined hepatocellular and cholangiocarcinoma, SHC separated hepatocellular carcinoma and intrahepatic cholangiocarcinoma, HCC hepatocellular carcinoma, ICC intrahepatic cholangiocarcinoma, HBsAg 15 hepatitis B surface antigen, AFP ɑ-fetoprotein, CA19-9 carbohydrate antigen 19-9, ▲ HCC, ▼ ICC
  2. aThese values are presented as median followed by range in the parentheses
  3. bThese data are presented as mean ±standard deviation; other values are presented as number of patients followed by percentage in the parentheses
  4. c P value for V1 CHC versus SHC; V2 CHC versus pure HCC; V3 CHC versus pure ICC
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Cancer Communications

ISSN: 2523-3548

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