|
Adverse event
|
All gradesb
|
Grade 3/4c
|
|---|
|
Overall adverse events
|
24 (88.9)
|
10 (37.0)
|
|
Fever
|
13 (48.1)
|
0 (0.0)
|
|
AST elevation
|
13 (48.1)
|
5 (18.5)
|
|
ALT elevation
|
12 (44.4)
|
2 (7.4)
|
|
Leukopenia
|
7 (25.9)
|
3 (11.1)
|
|
Rash
|
4 (14.8)
|
0 (0.0)
|
|
Neutropenia
|
4 (14.8)
|
3 (11.1)
|
|
Thrombocytopenia
|
3 (11.1)
|
2 (7.4)
|
|
Blood bilirubin elevation
|
2 (7.4)
|
1 (3.7)
|
|
Creatinine elevation
|
2 (7.4)
|
0 (0.0)
|
|
Upper respiratory infection
|
2 (7.4)
|
0 (0.0)
|
|
Uric acid elevation
|
1 (3.7)d
|
1 (3.7)
|
- Only those toxicities deemed possibly, probably, or definitely related to the treatment are included in the table. Note: a patient may have had more than one adverse event
-
AST aspartate aminotransferase, ALT alanine aminotransferase
-
aAdverse events were assessed according to the Common Toxicity Criteria for Adverse Events. Data are presented as number of patients followed by percentage in the parentheses
-
bAdverse event reported in at least 5% of the treated patients
-
cAll patients with grade 3 or 4 adverse events
-
dAlthough uric acid elevation occurred in only 1 patient (<5%), this adverse event was listed because it was grade 3
