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Table 5 Stratification analysis for association between variant genotypes and OSCC risk

From: Association of microRNA polymorphisms with the risk of head and neck squamous cell carcinoma in a Chinese population: a case–control study

Variable

miR-605 rs2043556 genotype (GG/AG/AA)a

Adjusted OR (95% CI)b

P b

miR-196a2 rs11614913 genotype (GG/AG/AA)a

Adjusted OR (95% CI)b

P b

Combined effect (0-2/3-4 risk alleles)c

Adjusted OR (95% CI)b

P b

Cancer patients (number)

Controls (number)

Cancer patients (number)

Controls (number)

Cancer patients (number)

Controls (number)

Age (years)

  

 <60

10/75/125

55/296/366

0.76 (0.59–1.00)

0.042

56/98/57

135/352/230

1.33 (1.07–1.66)

0.011

102/105

398/317

1.32 (0.97–1.81)

0.081

 ≥60

13/85/153

64/335/432

0.73 (0.58–0.93)

0.011

56/130/65

157/403/273

1.24 (1.01–1.52)

0.038

117/137

480/351

1.62 (1.22–2.16)

0.001

Sex

  

 Female

12/68/124

41/227/296

0.78 (0.60–1.02)

0.068

59/99/46

93/275/197

1.64 (1.30–2.07)

<0.001

97/107

331/233

1.54 (1.11–2.12)

0.010

 Male

11/92/154

78/404/502

0.72 (0.57–0.91)

0.005

53/129/76

199/480/306

1.08 (0.89–1.32)

0.434

122/135

547/435

1.47 (1.11–1.94)

0.008

Smoking

  

 Never

15/99/160

70/363/456

0.79 (0.63–0.99)

0.037

74/129/72

172/430/288

1.32 (1.09–1.60)

0.004

135/139

503/385

1.36 (1.03–1.79)

0.028

 Ever

8/61/118

49/268/342

0.66 (0.50–0.89)

0.006

38/99/50

120/325/215

1.25 (0.97–1.59)

0.081

84/103

375/283

1.72 (1.22–2.42)

0.002

Drinking

  

 Never

14/97/161

78/427/534

0.76 (0.60–0.95)

0.016

72/134/67

202/505/335

1.38 (1.14–1.67)

0.001

130/142

582/456

1.46 (1.11–1.92)

0.006

 Ever

9/63/117

41/204/264

0.70 (0.53–0.93)

0.014

40/94/55

90/250/168

1.18 (0.93–1.51)

0.175

89/100

296/212

1.58 (1.12–2.22)

0.009

  1. Italic value indicate significance of p value (p < 0.05)
  2. aThese data are presented as the numbers of cases with genotypes GG, AG, or AA
  3. bAdjusted by age, sex, smoking status, and drinking status
  4. cThese data are presented as the numbers of cases with 0–2 or 3–4 risk alleles
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Cancer Communications

ISSN: 2523-3548

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