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Table 5 Stratification analysis for association between variant genotypes and OSCC risk

From: Association of microRNA polymorphisms with the risk of head and neck squamous cell carcinoma in a Chinese population: a case–control study

Variable miR-605 rs2043556 genotype (GG/AG/AA)a Adjusted OR (95% CI)b P b miR-196a2 rs11614913 genotype (GG/AG/AA)a Adjusted OR (95% CI)b P b Combined effect (0-2/3-4 risk alleles)c Adjusted OR (95% CI)b P b
Cancer patients (number) Controls (number) Cancer patients (number) Controls (number) Cancer patients (number) Controls (number)
Age (years)   
 <60 10/75/125 55/296/366 0.76 (0.591.00) 0.042 56/98/57 135/352/230 1.33 (1.071.66) 0.011 102/105 398/317 1.32 (0.97–1.81) 0.081
 ≥60 13/85/153 64/335/432 0.73 (0.580.93) 0.011 56/130/65 157/403/273 1.24 (1.011.52) 0.038 117/137 480/351 1.62 (1.222.16) 0.001
Sex   
 Female 12/68/124 41/227/296 0.78 (0.60–1.02) 0.068 59/99/46 93/275/197 1.64 (1.302.07) <0.001 97/107 331/233 1.54 (1.112.12) 0.010
 Male 11/92/154 78/404/502 0.72 (0.570.91) 0.005 53/129/76 199/480/306 1.08 (0.89–1.32) 0.434 122/135 547/435 1.47 (1.111.94) 0.008
Smoking   
 Never 15/99/160 70/363/456 0.79 (0.630.99) 0.037 74/129/72 172/430/288 1.32 (1.091.60) 0.004 135/139 503/385 1.36 (1.031.79) 0.028
 Ever 8/61/118 49/268/342 0.66 (0.500.89) 0.006 38/99/50 120/325/215 1.25 (0.97–1.59) 0.081 84/103 375/283 1.72 (1.222.42) 0.002
Drinking   
 Never 14/97/161 78/427/534 0.76 (0.600.95) 0.016 72/134/67 202/505/335 1.38 (1.141.67) 0.001 130/142 582/456 1.46 (1.111.92) 0.006
 Ever 9/63/117 41/204/264 0.70 (0.530.93) 0.014 40/94/55 90/250/168 1.18 (0.93–1.51) 0.175 89/100 296/212 1.58 (1.122.22) 0.009
  1. Italic value indicate significance of p value (p < 0.05)
  2. aThese data are presented as the numbers of cases with genotypes GG, AG, or AA
  3. bAdjusted by age, sex, smoking status, and drinking status
  4. cThese data are presented as the numbers of cases with 0–2 or 3–4 risk alleles