|
Number of risk allelesa
|
Patients [number (%)]
|
Controls [number (%)]
|
Adjust OR (95% CI)b
|
P
b
|
|---|
|
0–1
|
66 (14.3)
|
303 (19.6)
|
1.00
| |
|
2
|
153 (33.2)
|
575 (37.2)
|
1.20 (0.87–1.66)
|
0.262
|
|
3
|
168 (36.4)
|
517 (33.4)
|
1.51 (1.10–2.09)
|
0.011
|
|
4
|
74 (16.1)
|
151 (9.8)
|
2.23 (1.51–3.29)
|
<0.001
|
|
Trend
|
NA
|
NA
|
1.21 (1.10–1.32)
|
<0.001
|
|
Binary classification
| | | |
<0.001
|
|
0–2
|
219 (47.5)
|
878 (56.8)
|
1.00
|
|
3–4
|
242 (52.5)
|
668 (43.2)
|
1.48 (1.20–1.83)
|
- Italic value indicate significance of p value (p < 0.05)
-
aThe miR-605 rs2043556 A and miR-196a2 rs11614913 G allele were assumed as risk alleles based on the main effect of the individual locus and were genotyped in the 461 OSCC cases and 1546 controls
-
bAdjusted by age, sex, smoking status, and drinking status
