Association of microRNA polymorphisms with the risk of head and neck squamous cell carcinoma in a Chinese population: a case–control study

Table 4 Combined effects of miR-605 rs2043556 and miR-196a2 rs11614913 on oral squamous cell carcinoma (OSCC) risk

Number of risk alleles^a	Patients [number (%)]	Controls [number (%)]	Adjust OR (95% CI)^b	P ^b
0–1	66 (14.3)	303 (19.6)	1.00
2	153 (33.2)	575 (37.2)	1.20 (0.87–1.66)	0.262
3	168 (36.4)	517 (33.4)	1.51 (1.10–2.09)	0.011
4	74 (16.1)	151 (9.8)	2.23 (1.51–3.29)	<0.001
Trend	NA	NA	1.21 (1.10–1.32)	<0.001
Binary classification				<0.001
0–2	219 (47.5)	878 (56.8)	1.00
3–4	242 (52.5)	668 (43.2)	1.48 (1.20–1.83)

Italic value indicate significance of p value (p < 0.05)
^aThe miR-605 rs2043556 A and miR-196a2 rs11614913 G allele were assumed as risk alleles based on the main effect of the individual locus and were genotyped in the 461 OSCC cases and 1546 controls
^bAdjusted by age, sex, smoking status, and drinking status

ISSN: 2523-3548