SNP
|
Genotypea
|
Controls [number (%)]
|
Oral cancer patients [number (%)]
|
Adjusted OR (95% CI)b
|
P
b
|
P
c
|
Non-oral cancer patients [number (%)]
|
Adjusted OR (95% CI)b
|
P
b
|
---|
miR-605 rs2043556
|
AA
|
798 (51.6)
|
278 (60.3)
|
1.00
|
55 (48.2)
|
1.00
| |
AG
|
631 (40.8)
|
160 (34.7)
|
0.74 (0.59–0.93)
|
0.009
|
0.045
|
52 (45.6)
|
1.19 (0.80–1.78)
|
0.396
|
GG
|
119 (7.7)
|
23 (5.0)
|
0.56 (0.35–0.89)
|
0.015
|
0.038
|
7 (6.1)
|
0.85 (0.38–1.94)
|
0.708
|
Dominant model
|
NA
|
NA
|
0.71 (0.58–0.88)
|
0.002
|
0.010
|
NA
|
1.14 (0.77–1.67)
|
0.518
|
Recessive model
|
NA
|
NA
|
0.63 (0.40–1.00)
|
0.050
|
0.125
|
NA
|
0.79 (0.36–1.75)
|
0.561
|
Additive model
|
NA
|
NA
|
0.74 (0.62–0.89)
|
0.001
|
0.005
|
NA
|
1.04 (0.77–1.42)
|
0.787
|
miR-196a2 rs11614913
|
AA
|
503 (32.5)
|
122 (26.4)
|
1.00
|
40 (35.1)
|
1.00
| |
AG
|
755 (48.7)
|
228 (49.4)
|
1.25 (0.98–1.61)
|
0.075
|
0.188
|
56 (49.1)
|
0.93 (0.61–1.43)
|
0.736
|
GG
|
292 (18.8)
|
112 (24.2)
|
1.64 (1.22–2.21)
|
0.001
|
0.005
|
18 (15.8)
|
0.76 (0.43–1.37)
|
0.366
|
Dominant model
|
NA
|
NA
|
1.36 (1.08–1.72)
|
0.010
|
0.025
|
NA
|
0.88 (0.59–1.33)
|
0.547
|
Recessive model
|
NA
|
NA
|
1.42 (1.11–1.83)
|
0.006
|
0.030
|
NA
|
0.80 (0.47–1.35)
|
0.402
|
Additive model
|
NA
|
NA
|
1.28 (1.10–1.48)
|
0.001
|
0.003
|
NA
|
0.88 (0.67–1.17)
|
0.386
|
miR-149 rs2292832
|
AA
|
726
|
226
|
1.00
|
57
|
1.00
| |
AG
|
647
|
193
|
0.96 (0.77–1.19)
|
0.696
|
0.696
|
38
|
0.76 (0.49–1.17)
|
0.206
|
GG
|
175
|
42
|
0.76 (0.52–1.10)
|
0.141
|
0.235
|
19
|
1.37 (0.79–2.39)
|
0.268
|
Dominant model
|
NA
|
NA
|
0.91 (0.74–1.13)
|
0.399
|
0.499
|
NA
|
0.89 (0.60–1.31)
|
0.556
|
Recessive model
|
NA
|
NA
|
0.77 (0.54–1.10)
|
0.156
|
0.260
|
NA
|
1.55 (0.91–2.62)
|
0.107
|
Additive model
|
NA
|
NA
|
0.90 (0.77–1.06)
|
0.198
|
0.248
|
NA
|
1.05 (0.79–1.39)
|
0.735
|
miR-146a rs2910164
|
GG
|
497
|
154
|
1.00
|
40
| | |
GC
|
773
|
228
|
0.95 (0.75–1.21)
|
0.685
|
0.861
|
53
|
0.82 (0.53–1.27)
|
0.376
|
CC
|
278
|
80
|
0.93 (0.68–1.27)
|
0.656
|
0.656
|
21
|
0.90 (0.51–1.57)
|
0.702
|
Dominant model
|
NA
|
NA
|
0.95 (0.76–1.18)
|
0.633
|
0.633
|
NA
|
0.84 (0.56–1.27)
|
0.407
|
Recessive model
|
NA
|
NA
|
0.96 (0.73–1.27)
|
0.771
|
0.771
|
NA
|
1.01 (0.61–1.66)
|
0.975
|
Additive model
|
NA
|
NA
|
0.96 (0.83–1.12)
|
0.629
|
0.629
|
NA
|
0.93 (0.70–1.23)
|
0.589
|
miR-608 rs4919510
|
AA
|
509
|
137
|
1.00
|
40
| | |
AG
|
762
|
232
|
1.14 (0.90–1.45)
|
0.283
|
0.472
|
53
|
0.85 (0.55–1.31)
|
0.464
|
GG
|
278
|
93
|
1.23 (0.91–1.67)
|
0.179
|
0.224
|
21
|
0.97 (0.56–1.70)
|
0.927
|
Dominant model
|
NA
|
NA
|
1.17 (0.93–1.46)
|
0.187
|
0.312
|
NA
|
0.88 (0.59–1.32)
|
0.546
|
|
Recessive model
|
NA
|
NA
|
1.14 (0.87–1.48)
|
0.345
|
0.431
|
NA
|
1.07 (0.65–1.77)
|
0.787
|
|
Additive model
|
NA
|
NA
|
1.11 (0.96–1.29)
|
0.160
|
0.267
|
NA
|
0.96 (0.73–1.28)
|
0.794
|
- Italic value indicate significance of p value (p < 0.05)
-
NA not available
-
a
miR-605 rs2043556 was genotyped in 575 cases and 1548 controls; miR-196a2 was genotyped in 576 cases and 1550 controls; miR-149 rs2292832 was genotyped in 575 cases and 1548 controls; miR-146a rs2910164 was genotyped in 576 cases and 1548 controls; and miR-608 rs4919510 was genotyped in 576 cases and 1549 controls
-
bAdjusted by age, sex, smoking status, and drinking status
-
c
P values of multiple comparisons for false discovery rate using the FDR method (n = 5, refer to the number of SNPs)