Table 3 Logistic regression analysis for associations between selected SNPs and HNSCC risk
SNP | Genotypea | Controls [number (%)] | Oral cancer patients [number (%)] | Adjusted OR (95% CI)b | P b | P c | Non-oral cancer patients [number (%)] | Adjusted OR (95% CI)b | P b |
|---|---|---|---|---|---|---|---|---|---|
miR-605 rs2043556 | AA | 798 (51.6) | 278 (60.3) | 1.00 | 55 (48.2) | 1.00 | |||
AG | 631 (40.8) | 160 (34.7) | 0.74 (0.59–0.93) | 0.009 | 0.045 | 52 (45.6) | 1.19 (0.80–1.78) | 0.396 | |
GG | 119 (7.7) | 23 (5.0) | 0.56 (0.35–0.89) | 0.015 | 0.038 | 7 (6.1) | 0.85 (0.38–1.94) | 0.708 | |
Dominant model | NA | NA | 0.71 (0.58–0.88) | 0.002 | 0.010 | NA | 1.14 (0.77–1.67) | 0.518 | |
Recessive model | NA | NA | 0.63 (0.40–1.00) | 0.050 | 0.125 | NA | 0.79 (0.36–1.75) | 0.561 | |
Additive model | NA | NA | 0.74 (0.62–0.89) | 0.001 | 0.005 | NA | 1.04 (0.77–1.42) | 0.787 | |
miR-196a2 rs11614913 | AA | 503 (32.5) | 122 (26.4) | 1.00 | 40 (35.1) | 1.00 | |||
AG | 755 (48.7) | 228 (49.4) | 1.25 (0.98–1.61) | 0.075 | 0.188 | 56 (49.1) | 0.93 (0.61–1.43) | 0.736 | |
GG | 292 (18.8) | 112 (24.2) | 1.64 (1.22–2.21) | 0.001 | 0.005 | 18 (15.8) | 0.76 (0.43–1.37) | 0.366 | |
Dominant model | NA | NA | 1.36 (1.08–1.72) | 0.010 | 0.025 | NA | 0.88 (0.59–1.33) | 0.547 | |
Recessive model | NA | NA | 1.42 (1.11–1.83) | 0.006 | 0.030 | NA | 0.80 (0.47–1.35) | 0.402 | |
Additive model | NA | NA | 1.28 (1.10–1.48) | 0.001 | 0.003 | NA | 0.88 (0.67–1.17) | 0.386 | |
miR-149 rs2292832 | AA | 726 | 226 | 1.00 | 57 | 1.00 | |||
AG | 647 | 193 | 0.96 (0.77–1.19) | 0.696 | 0.696 | 38 | 0.76 (0.49–1.17) | 0.206 | |
GG | 175 | 42 | 0.76 (0.52–1.10) | 0.141 | 0.235 | 19 | 1.37 (0.79–2.39) | 0.268 | |
Dominant model | NA | NA | 0.91 (0.74–1.13) | 0.399 | 0.499 | NA | 0.89 (0.60–1.31) | 0.556 | |
Recessive model | NA | NA | 0.77 (0.54–1.10) | 0.156 | 0.260 | NA | 1.55 (0.91–2.62) | 0.107 | |
Additive model | NA | NA | 0.90 (0.77–1.06) | 0.198 | 0.248 | NA | 1.05 (0.79–1.39) | 0.735 | |
miR-146a rs2910164 | GG | 497 | 154 | 1.00 | 40 | ||||
GC | 773 | 228 | 0.95 (0.75–1.21) | 0.685 | 0.861 | 53 | 0.82 (0.53–1.27) | 0.376 | |
CC | 278 | 80 | 0.93 (0.68–1.27) | 0.656 | 0.656 | 21 | 0.90 (0.51–1.57) | 0.702 | |
Dominant model | NA | NA | 0.95 (0.76–1.18) | 0.633 | 0.633 | NA | 0.84 (0.56–1.27) | 0.407 | |
Recessive model | NA | NA | 0.96 (0.73–1.27) | 0.771 | 0.771 | NA | 1.01 (0.61–1.66) | 0.975 | |
Additive model | NA | NA | 0.96 (0.83–1.12) | 0.629 | 0.629 | NA | 0.93 (0.70–1.23) | 0.589 | |
miR-608 rs4919510 | AA | 509 | 137 | 1.00 | 40 | ||||
AG | 762 | 232 | 1.14 (0.90–1.45) | 0.283 | 0.472 | 53 | 0.85 (0.55–1.31) | 0.464 | |
GG | 278 | 93 | 1.23 (0.91–1.67) | 0.179 | 0.224 | 21 | 0.97 (0.56–1.70) | 0.927 | |
Dominant model | NA | NA | 1.17 (0.93–1.46) | 0.187 | 0.312 | NA | 0.88 (0.59–1.32) | 0.546 | |
Recessive model | NA | NA | 1.14 (0.87–1.48) | 0.345 | 0.431 | NA | 1.07 (0.65–1.77) | 0.787 | |
Additive model | NA | NA | 1.11 (0.96–1.29) | 0.160 | 0.267 | NA | 0.96 (0.73–1.28) | 0.794 | |