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Table 1 Prognostic factors for DFS and OS of patients with intrahepatic cholangiocarcinoma determined by using univariate and multivariate Cox regression models

From: EYA4 gene functions as a prognostic marker and inhibits the growth of intrahepatic cholangiocarcinoma

Variable DFS OS
HR 95% CI P value HR 95% CI P value
Univariate
Sex (women vs. men) 0.820 0.532–1.265 0.370 0.853 0.549–1.324 0.478
Age (<65 years vs. ≥65 years) 1.088 0.659–1.797 0.741 0.984 0.583–1.661 0.953
Liver cirrhosis (yes vs. no) 1.410 0.706–2.816 0.331 1.055 0.508–2.191 0.885
EYA4 protein expressiona (≤3.4 vs. >3.4) 2.635 1.684–4.122 <0.001 2.730 1.727–4.314 <0.001
CA19-9 (>37 U/L vs. ≤37 U/L) 1.753 1.107–2.778 0.017 1.955 1.214–3.147 0.006
CEA (>5 µg/L vs. ≤5 µg/L) 1.665 1.077–2.574 0.022 1.764 1.128–2.758 0.013
Size of tumor (≤5 cm vs. >5 cm) 0.983 0.631–1.529 0.938 1.047 0.667–1.643 0.841
Number of tumors (multiple vs. single) 2.469 1.521–4.006 <0.001 2.921 1.809–4.717 <0.001
Vascular invasion (yes vs. no) 1.803 0.899–3.616 0.097 2.049 1.053–3.989 0.055
Adjacent organ invasion (yes vs. no) 2.489 1.388–4.462 0.002 3.328 1.851–5.984 <0.001
Lymph node metastasis (yes vs. no) 2.410 1.558–3.728 <0.001 2.279 1.460–3.558 <0.001
Tumor differentiation (poor vs. moderate vs. well) 2.009 1.366–2.953 <0.001 2.272 1.540–3.353 <0.001
Multivariate
EYA4 protein expressiona (≤3.4 vs. >3.4) 1.730 1.060–2.823 0.028 1.781 1.093–2.902 0.021
Number of tumors (multiple vs. single) 2.008 1.201–3.357 0.008 2.494 1.508–4.124 <0.001
Adjacent organ invasion (yes vs. no) 2.325 1.238–4.367 0.009 3.765 1.954–7.253 0.001
Lymph node metastasis (yes vs. no) 1.919 1.181–3.120 0.009 1.798 1.106–2.921 0.018
Tumor differentiation (poor vs. moderate vs. well) 2.053 1.301–3.238 0.002 2.530 1.578–4.055 <0.001
  1. EYA4 Eyes absent homolog 4; CA19-9 carbohydrate antigen 19-9; CEA carcino-embryonic antigen; DFS disease-free survival; OS overall survival; HR hazard ratio; CI confidence interval
  2. aImmunohistochemical (IHC) score, split at median