Table 1 Prognostic factors for DFS and OS of patients with intrahepatic cholangiocarcinoma determined by using univariate and multivariate Cox regression models

Univariate

Sex (women vs. men)

0.532–1.265

0.549–1.324

Age (<65 years vs. ≥65 years)

0.659–1.797

0.583–1.661

Liver cirrhosis (yes vs. no)

0.706–2.816

0.508–2.191

EYA4 protein expression^a (≤3.4 vs. >3.4)

1.684–4.122

1.727–4.314

CA19-9 (>37 U/L vs. ≤37 U/L)

1.107–2.778

1.214–3.147

CEA (>5 µg/L vs. ≤5 µg/L)

1.077–2.574

1.128–2.758

Size of tumor (≤5 cm vs. >5 cm)

0.631–1.529

0.667–1.643

Number of tumors (multiple vs. single)

1.521–4.006

1.809–4.717

Vascular invasion (yes vs. no)

0.899–3.616

1.053–3.989

Adjacent organ invasion (yes vs. no)

1.388–4.462

1.851–5.984

Lymph node metastasis (yes vs. no)

1.558–3.728

1.460–3.558

Tumor differentiation (poor vs. moderate vs. well)

1.366–2.953

1.540–3.353

Multivariate

EYA4 protein expression^a (≤3.4 vs. >3.4)

1.060–2.823

1.093–2.902

Number of tumors (multiple vs. single)

1.201–3.357

1.508–4.124

Adjacent organ invasion (yes vs. no)

1.238–4.367

1.954–7.253

Lymph node metastasis (yes vs. no)

1.181–3.120

1.106–2.921

Tumor differentiation (poor vs. moderate vs. well)

1.301–3.238

1.578–4.055