Fig. 2

The pathologic findings before neoCRT and after surgery of a patient with LASCC (hematoxylin and eosin staining). a, b Pathologic examination of the sigmoid colon biopsy before neoCRT shows typical features of a well-differentiated adenocarcinoma: hyperplastic glandular structures lined by atypical epithelial cells. Mitotic figures are observed. c Postoperative pathologic examination shows lymphoid infiltrates in intestinal mucosa. No malignant cells are observed