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Table 2 Univariate and multivariate regression analysis on the association between patient characteristics and LNN
| Variable | Univariate analysis | Multivariate analysis | ||||
|---|---|---|---|---|---|---|
| OR | 95% CI | P | AOR | 95% CI | P | |
| Sex (women vs. men) | 3.308 | 1.468–7.454 | 0.004 | 3.354 | 1.367–8.231 | 0.008 |
| Age (≥39.5 vs. <39.5 years) | 2.302 | 0.763–6.947 | 0.139 | – | – | – |
| Initial radiation dose (≥74.68 vs. <74.68 Gy) | 1.836 | 0.672–5.018 | 0.236 | – | – | – |
| Recurrent stage (I vs. II vs. III vs. IV) | – | – | 0.999 | – | – | – |
| Interval of recurrence (≥25.5 vs. <25.5 months) | 1.435 | 0.623–3.207 | 0.396 | – | – | – |
| CCT during re-irradiation (yes vs. no) | 0.672 | 0.283–1.594 | 0.367 | – | – | – |
| Necrosis before re-irradiation (yes vs. no) | 3.136 | 1.374–7.160 | 0.007 | 3.469 | 1.382–8.710 | 0.008 |
| Re-irradiation GTV dose (≥ 67 vs. < 67 Gy) | 1.509 | 0.691–3.296 | 0.302 | – | – | – |
| Mean re-irradiation dose (≥71.97 vs. < 71.97 Gy) | 2.481 | 1.118–5.509 | 0.026 | 1.713 | 0.691–4.248 | 0.246 |
| Re-irradiation fractionated dose (≥ 2.3 vs. < 2.3 Gy) | – | – | 0.999 | – | – | – |
| Duration of re-irradiation (≥ 49.5 vs. < 49.5 days) | 2.268 | 0.907–5.672 | 0.08 | – | – | – |
| Accumulated total GTV dose (≥141.5 vs. <141.5 Gy) | 3.220 | 1.108–9.357 | 0.032 | 3.763 | 1.041–13.611 | 0.043 |
| Recurrent tumor volume (≥25.38 vs. <25.38 cm3) | 4.467 | 1.302–15.322 | 0.017 | 6.063 | 1.561–23.543 | 0.009 |
| BMI (≥19.8 vs. <19.8) | 1.421 | 0.547–3.691 | 0.470 | – | – | – |
