Skip to main content

Table 2 Univariate and multivariate regression analysis on the association between patient characteristics and LNN

From: A model to predict the risk of lethal nasopharyngeal necrosis after re-irradiation with intensity-modulated radiotherapy in nasopharyngeal carcinoma patients

Variable

Univariate analysis

Multivariate analysis

OR

95% CI

P

AOR

95% CI

P

Sex (women vs. men)

3.308

1.468–7.454

0.004

3.354

1.367–8.231

0.008

Age (≥39.5 vs. <39.5 years)

2.302

0.763–6.947

0.139

–

–

–

Initial radiation dose (≥74.68 vs. <74.68 Gy)

1.836

0.672–5.018

0.236

–

–

–

Recurrent stage (I vs. II vs. III vs. IV)

–

–

0.999

–

–

–

Interval of recurrence (≥25.5 vs. <25.5 months)

1.435

0.623–3.207

0.396

–

–

–

CCT during re-irradiation (yes vs. no)

0.672

0.283–1.594

0.367

–

–

–

Necrosis before re-irradiation (yes vs. no)

3.136

1.374–7.160

0.007

3.469

1.382–8.710

0.008

Re-irradiation GTV dose (≥ 67 vs. < 67 Gy)

1.509

0.691–3.296

0.302

–

–

–

Mean re-irradiation dose (≥71.97 vs. < 71.97 Gy)

2.481

1.118–5.509

0.026

1.713

0.691–4.248

0.246

Re-irradiation fractionated dose (≥ 2.3 vs. < 2.3 Gy)

–

–

0.999

–

–

–

Duration of re-irradiation (≥ 49.5 vs. < 49.5 days)

2.268

0.907–5.672

0.08

–

–

–

Accumulated total GTV dose (≥141.5 vs. <141.5 Gy)

3.220

1.108–9.357

0.032

3.763

1.041–13.611

0.043

Recurrent tumor volume (≥25.38 vs. <25.38 cm3)

4.467

1.302–15.322

0.017

6.063

1.561–23.543

0.009

BMI (≥19.8 vs. <19.8)

1.421

0.547–3.691

0.470

–

–

–

  1. LNN lethal nasopharyngeal necrosis, CI, confidence interval, CCT concurrent chemoradiotherapy, GTV gross tumor volume, BMI body mass index, OR odds ratio, AOR adjusted odds ratio