Table 2 Univariate and multivariate Cox regression analyses of clinicopathologic variables of patients with early-stage cervical squamous cell cancer for overall survival
Variable | Univariate analysis | Multivariate analysis | ||||
|---|---|---|---|---|---|---|
HR | 95% CI | P value | HR | 95% CI | P value | |
Age (>45 vs. ≤45 years) | 2.906 | 0.911–9.268 | 0.071 | |||
Tumor size (>4 vs. ≤4 cm) | 0.608 | 0.239–1.545 | 0.295 | |||
Tumor grade (1 + 2 vs. 3) | 1.239 | 0.446–3.441 | 0.681 | |||
SCC antigen level (>1.5 vs. ≤1.5 ng/mL) | 1.477 | 0.512–4.264 | 0.471 | |||
FIGO stage (IB1 + IB2 + IIA1 vs. IIB) | 2.111 | 1.313–3.392 | 0.002 | 2.876 | 1.582–5.229 | 0.001 |
Pelvic lymph node metastasis (present vs. absent) | 3.569 | 1.237–10.294 | 0.019 | 0.291 | 0.047–1.789 | 0.183 |
Deep cervical stromal invasion (present vs. absent) | 5.385 | 1.205–24.065 | 0.028 | 1.548 | 0.266–8.999 | 0.626 |
Lymphovascular space invasion (present vs. absent) | 13.212 | 4.575–38.156 | <0.001 | 19.284 | 5.958–62.419 | <0.001 |
PTK6 expression (high vs. low) | 4.763 | 1.326–17.112 | 0.017 | 5.999 | 1.622–22.191 | 0.007 |